1. Pulse wave velocity predicts cardiovascular mortality: findings from the Hawaii-Los Angeles-Hiroshima study.
- Author
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Shokawa T, Imazu M, Yamamoto H, Toyofuku M, Tasaki N, Okimoto T, Yamane K, and Kohno N
- Subjects
- Aged, Americas epidemiology, Aorta, Abdominal physiology, Cardiovascular Diseases diagnosis, Cause of Death, Cohort Studies, Electrocardiography, Electrodiagnosis standards, Female, Femoral Artery physiology, Follow-Up Studies, Humans, Japan ethnology, Male, Middle Aged, Pulsatile Flow, Pulse, ROC Curve, Risk Factors, Survival Analysis, Cardiovascular Diseases mortality, Electrodiagnosis methods
- Abstract
Background: Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term cardiovascular mortality in general populations., Methods and Results: We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 +/-8.8 years) to assess the relationship between PWV and cardiovascular disease mortality and all-cause mortality. During the 10-year follow-up, 43 patients died (14 from cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for cardiovascular mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively., Conclusions: The present study demonstrated that an increased PWV value is associated with future cardiovascular disease death in Japanese-Americans living in Hawaii.
- Published
- 2005
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