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With the increasing severity of the global energy crisis and environmental pollution, there is an urgent need to change the economic development model driven by certain factors and the investment scale and pursue science- and technology-driven innovative development. This study aims to improve the efficiency of scientific and technological innovation and promote the high-quality development of regional industrial enterprises. It constructs a data-driven DEA-Malmquist evaluation model to evaluate and optimize regional industrial enterprises' scientific and technological innovation efficiency. First, we collect the panel data of regional industrial enterprises' scientific and technological innovation input-output indexes. Second, we use the Pearson correlation coefficient method to identify and construct the evaluation index system of regional industrial enterprises' scientific and technological innovation efficiency. Third, we build a DEA-Malmquist evaluation model to quantitatively evaluate regional industrial enterprises' scientific and technological innovation efficiency from static and dynamic aspects. Finally, we verify the feasibility and effectiveness of the method using statistical data on scientific and technological innovation and development of Anhui industrial enterprises from 2011 to 2019 and put forth targeted countermeasures and suggestions. This study provides theoretical and methodological support for the sustainable development of industrial enterprises. [ABSTRACT FROM AUTHOR]