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Previous findings show that large-scale atmospheric circulation plays an important role in driving Arctic sea ice variability from synoptic to seasonal time scales. While some circulation patterns responsible for Barents–Kara sea ice changes have been identified in previous works, the most important patterns and the role of their persistence remain unclear. Our study uses self-organizing maps to identify nine high-latitude circulation patterns responsible for day-to-day Barents–Kara sea ice changes. Circulation patterns with a high pressure center over the Urals (Scandinavia) and a low pressure center over Iceland (Greenland) are found to be the most important for Barents–Kara sea ice loss. Their opposite-phase counterparts are found to be the most important for sea ice growth. The persistence of these circulation patterns helps explain sea ice variability from synoptic to seasonal time scales. We further use sea ice models forced by observed atmospheric fields (including the surface circulation and temperature) to reproduce observed sea ice variability and diagnose the role of atmosphere-driven thermodynamic and dynamic processes. Results show that thermodynamic and dynamic processes similarly contribute to Barents–Kara sea ice concentration changes on synoptic time scales via circulation. On seasonal time scales, thermodynamic processes seem to play a stronger role than dynamic processes. Overall, our study highlights the importance of large-scale atmospheric circulation, its persistence, and varying physical processes in shaping sea ice variability across multiple time scales, which has implications for seasonal sea ice prediction. Significance Statement: Understanding what processes lead to Arctic sea ice changes is important due to their significant impacts on the ecosystem, weather, and shipping, and hence our society. A well-known process that causes sea ice changes is atmospheric circulation variability. We further pin down what circulation patterns and underlying mechanisms matter. We identify multiple circulation patterns responsible for sea ice loss and growth to different extents. We find that the circulation can cause sea ice loss by mechanically pushing sea ice northward and bringing warm and moist air to melt sea ice. The two processes are similarly important. Our study advances understanding of the Arctic sea ice variability with important implications for Arctic sea ice prediction. [ABSTRACT FROM AUTHOR]