1. Cytotoxic terpenoids from Nardophyllum bryoides
- Author
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Sánchez, Marianela, Mazzuca, Marcia, Veloso, María José, Fernández, Lucía R., Siless, Gastón, Puricelli, Lydia, and Palermo, Jorge A.
- Subjects
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CELL-mediated cytotoxicity , *TERPENES , *ETHANOL , *PLANT extracts , *PLANT physiology - Abstract
Abstract: The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1–3), two ent-halimanes (4–5) and six pentacyclic oleanane and ursane triterpenoids (6–11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound. [Copyright &y& Elsevier]
- Published
- 2010
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