1. Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile.
- Author
-
Wächter GA, Valcic S, Flagg ML, Franzblau SG, Montenegro G, Suarez E, and Timmermann BN
- Subjects
- Antitubercular Agents chemistry, Argentina, Chile, Dose-Response Relationship, Drug, In Vitro Techniques, Medicine, Traditional, Microbial Sensitivity Tests, Mycobacterium tuberculosis drug effects, Structure-Activity Relationship, Triterpenes chemistry, Antitubercular Agents isolation & purification, Antitubercular Agents pharmacology, Plants, Medicinal chemistry, Triterpenes isolation & purification, Triterpenes pharmacology
- Abstract
Screening of plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several pentacyclic triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.
- Published
- 1999
- Full Text
- View/download PDF