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1. Sauroine, an alkaloid from Huperzia saururus with activity in wistar rats in electrophysiological and behavioral assays related to memory retention.

Author

Vallejo MG, Ortega MG, Cabrera JL, Carlini VP, de Barioglio SR, Almirón RS, Ramírez OA, and Agnese AM

Subjects
Alkaloids chemistry, Animals, Argentina, Hippocampus drug effects, Male, Motor Activity drug effects, Rats, Rats, Wistar, Alkaloids isolation & purification, Alkaloids pharmacology, Behavior drug effects, Huperzia chemistry, Memory drug effects, Plants, Medicinal chemistry
Abstract

The present study describes the effects of sauroine (1), the main alkaloid obtained from Huperzia saururus, on memory retention and learning. To evaluate this, electrophysiological experiments and behavioral tests (step down) were performed on male Wistar rats. The results showed that 1 improved memory retention in the step-down test, significantly increasing hippocampal plasticity. Thus, 1 seems to be a constituent responsible for the activity claimed in folk medicine for H. saururus in Argentina.

Published
2009
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