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The question of suspected nonaccidental trauma as a possible cause of injury for femoral shaft fractures in children is a troubling but common issue facing orthopedic surgeons. The purpose of this study is to analyze femoral shaft fractures at a major pediatric level I trauma center in a large metropolitan area over a 5-year period to determine the incidence of suspected nonaccidental trauma and the risk factors associated with that diagnosis. This study is a retrospective review of all children younger than 5 years at a large trauma center in a southwestern metropolitan area who presented with a femoral shaft fracture. Patient charts were reviewed to determine demographics, mechanism of injury, and fracture type. Referrals to social work and Child Protective Services were also reviewed to determine an overall incidence of suspected nonaccidental trauma.Over the 5-year study period, 137 patients presented to our institution with a femoral shaft fracture. Mean patient age at the time of injury was 2.2 years (range, 1 month to 4 years). Overall, 43 patients with a mean age of 1.8 years were determined to have injuries suspicious of nonaccidental trauma and were referred to Child Protective Services, giving an overall incidence of 31%. Age younger than 1 year was a highly significant risk factor for suspected nonaccidental trauma. Of the 20 children younger than 1 year, 18 (90%) were referred to Child Protective Services, comprising 42% of those children suspicious of nonaccidental trauma. The presence of either Medicaid or no insurance was a highly statistically significant risk factor for suspected nonaccidental trauma., (Copyright 2011, SLACK Incorporated.)