1. Antibiotic sensitivities of Neisseria gonorrhoeae in the Far East: comparison of plasmid species in isolates from six countries.
- Author
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Ng WW, Echeverria P, Rockhill R, and Duangmani C
- Subjects
- Ampicillin pharmacology, DNA genetics, Asia, Eastern, Gonorrhea microbiology, Humans, In Vitro Techniques, Kanamycin pharmacology, Male, Neisseria gonorrhoeae isolation & purification, Penicillinase metabolism, Penicillins pharmacology, Tetracycline pharmacology, beta-Lactamases biosynthesis, Anti-Bacterial Agents pharmacology, Neisseria gonorrhoeae drug effects, Plasmids drug effects
- Abstract
In vitro susceptibility testing of 36 strains of Neisseria gonorrhoeae isolated in the Far East in 1979 and 1980 demonstrated that 27 penicillinase-producing (PPNG) isolates and nine non-penicillinase-producing (non-PPNG) isolates were susceptible to chloramphenicol, thiamphenicol, spectinomycin, trimethoprim-sulfamethoxazole, cefoperazone, moxalactam, cefotaxime, and ceftriaxone. In comparison, 50% of the strains had MICs of tetracycline of greater than 2 micrograms/ml, and 75% had MICs, of streptomycin of greater than 128 micrograms/ml. Eighty-two per cent of PPNG and 100% of non-PPNG isolates examined had MICs of kanamycin of greater than 32 micrograms/ml. None of the nine non-PPNG strains had MICs of ampicillin and penicillin of greater than 1 microgram/ml. A 4.4-megadalton plasmid, previously associated with beta-lactamase production, was found in all 27 PPNG isolates examined; 93% of PPNG and 22% of non-PPNG isolates contained a 24-megadalton plasmid previously associated with transfer of the 4.4-megadalton plasmid.
- Published
- 1982
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