1. Apo E gene polymorphism affects development of type 2 diabetic nephropathy in Asian populations, especially in East Asians: an updated meta-analysis.
- Author
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Lin YJ, Pan JL, Jiang MJ, Tan JH, Zhong W, Gong TK, Jin XC, Cai SH, and Wu YJ
- Subjects
- Alleles, Case-Control Studies, Asia, Eastern ethnology, Humans, Publication Bias, Apolipoproteins E genetics, Asian People genetics, Diabetes Mellitus, Type 2 genetics, Diabetic Nephropathies genetics, Genetic Predisposition to Disease, Polymorphism, Genetic
- Abstract
Background: Many studies have determined the correlation between the Apolipoprotein E (APO E) gene polymorphisms and diabetic nephropathy, but their results are inconclusive., Material/methods: With the aim to confirm this correlation, we performed a meta-analysis of 16 studies. The dichotomous data are presented as the odds ratio (OR) with a 95% confidence interval (CI)., Results: The results of our study indicate that APO ε2 allele among the pooled Asian populations were more likely to show high risk of DN development (2 allele vs. ε3 allele: pooled OR =1.629, 95% CI=1.010-2.628, P=0.045). For further analysis, the APO e2 allele was associated with progress of DN in the group with duration >10 years, but not in the group with duration <10 years (ε2 allele vs. ε3 allele: pooled OR=1.920, 95% CI=1.338-2.754, P<0.001). The APO e2 polymorphism increased the susceptibility to DN in Asian population compared with healthy people (ε2 allele vs. ε3 allele: pooled OR=1.629, 95% CI=1.010-2.628, P=0.045)., Conclusions: Development of DN is associated with APO E polymorphisms in Asian populations, especially in East Asians.
- Published
- 2014
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