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1. Surface glycoproteins of an African henipavirus induce syncytium formation in a cell line derived from an African fruit bat, Hypsignathus monstrosus.

Author

Krüger N, Hoffmann M, Weis M, Drexler JF, Müller MA, Winter C, Corman VM, Gützkow T, Drosten C, Maisner A, and Herrler G

Subjects
Africa, Animals, Asia, Southeastern, Cell Line, Henipavirus genetics, Henipavirus Infections virology, Viral Envelope Proteins genetics, Chiroptera virology, Giant Cells virology, Henipavirus isolation & purification, Henipavirus metabolism, Henipavirus Infections veterinary, Viral Envelope Proteins metabolism
Abstract

Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus. Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.

Published
2013
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