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Aims: Child trafficking in South and Southeast Asia is widespread and deeply troubling. While several agencies have initiated anti-child-trafficking interventions, it is unknown whether they address the 21 social determinants of child trafficking identified by Perry and McEwing (2013). The aim of this integrative review was to explore the anti-child-trafficking strategies employed by governments and non-governmental organizations (NGOs) that target the social determinants of child trafficking in South and Southeast Asia, and identify which levels of the socio-ecological model (SEM) they address. Methods : The authors performed a literature search for journal articles and reports by researchers, local or national governments, and international organizations on the prevention of child trafficking in eight South Asian and eight Southeast Asian nations. Identified manuscripts were analyzed to determine which social determinants and socio-ecological levels were addressed by the programs described. Results : Sixteen journal articles and 31 reports from the gray literature were identified. The government and NGO anti-child-trafficking strategies in 16 South and Southeast Asian nations addressed 15 and 12 of the 21 social determinants, respectively. Social determinants at the intrapersonal, interpersonal, community, and policy levels of SEM were addressed, but failed to address the organizational level. Conclusions : The gravity of child trafficking necessitates that interventions address all of the 21 social determinants of child trafficking at all levels of the SEM. The authors found no account on any anti-child-trafficking intervention from four South Asian and five Southeast Asian nations. Dissemination and continuous evaluation of anti-trafficking interventions are warranted. [ABSTRACT FROM AUTHOR]