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• The guideline covers diagnosis, staging, risk assessment, treatment, disease monitoring and follow-up. • The multidisciplinary expert author group is from different institutions and countries in Europe, Asia and the USA. • Recommendations are based on available scientific data and the authors' collective expert opinion. • ESMO-MCBS and ESCAT scores provide levels of evidence for treatment choices, including targeted therapies. • In clinical practice, all recommendations provided need to be discussed with patients in a shared decision-making approach. [ABSTRACT FROM AUTHOR]