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Cellular redox homeostasis is compromised when exposed to internal or external stress factors, resulting in the superiority of the oxidant. It is known that these reactive oxygen species play a critical role in the etiology of many serious diseases like diabetes and cancer. Melanoma is the deadliest form of skin cancer and its rates are currently increasing faster than other preventable cancers. Melanoma is caused by the appearance of genetic mutations in pigment-producing cells, melanocytes. Ziziphus jujube Mill. spreads in regions of Asia with tropical/subtropical climates and has been used for thnds of years as basic traditional folk medicine. This study was carried out to determine the potential antioxidant effects of Ziziphus jujube on melanoma. Survival of cells was measured by MTT assay (colorimetric). Melanoma cells were treated three hours with 100% concentration Ziziphus jujube essential oil. Total antioxidant and oxidant capacity, glutathione, and nitric oxide levels were determined by spectrophotometrically. Ziziphus jujube prevented cell proliferation and increased total antioxidant capacity. Our results indicated that Ziziphus jujube inhibited the decrease in antioxidant levels and elevation of nitric oxide levels in melanoma cells. Also, the Ziziphus jujube administration improved GSH levels. Briefly, it can be concluded that Ziziphus jujube showed potential antioxidative and antiproliferative effects in melanoma cells. Recent research provides a detailed ethnopharmacological approach for the medicinal use of Ziziphus jujube fruit. [ABSTRACT FROM AUTHOR]