1. Genetic diversity of Alkhurma hemorrhagic fever virus in Western Asia.
- Author
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ul-Rahman, Aziz
- Subjects
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HEMORRHAGIC fever , *ARBOVIRUS diseases , *GENETIC epidemiology , *MOLECULAR epidemiology , *VIRUSES , *GENETIC markers - Abstract
Abstract Alkhurma hemorrhagic fever, caused by Alkhurma hemorrhagic fever virus (ALKV), is an arboviral infection which is further expanding in tropical and subtropical regions of the Western Asia. A number of Alkhurma hemorrhagic fever virus (ALKV) strains have been isolated from clinical cases representing Saudi Arabia and Egypt; however, the phylogenetic relationship of these particular isolates to those reported previously elsewhere in the world remains elusive. Based on the analysis of the envelope (E), and non-structural gene (NS3 and NS5), the phylogenetic and PASC analysis revealed the circulation of three sub-lineages (I-III) suggesting a continuous evolution. Also, the comparative genome analysis revealed the envelope gene to be a reliable genetic marker to elucidate the molecular epidemiology and genetic diversity of discrete strains of ALKV. Highlights • Over the past 24 years, human infection has become more predominant and, virus was isolated from clinical cases. • A number of alkhumra hemorrhagic fever virus (ALKV) has been isolated from different geography. • Despite of an increase in genetic diversity, its phylogenetic depiction is still incomplete • Study revealed that envelope gene can be a reliable evolutionary marker for classification at sub-lineage level. • The findings will be useful for global researchers to establish an accurate evolutionary link among prevailing strains. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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