1. The 5300-year-old Helicobacter pylori genome of the Iceman.
- Author
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Maixner F, Krause-Kyora B, Turaev D, Herbig A, Hoopmann MR, Hallows JL, Kusebauch U, Vigl EE, Malfertheiner P, Megraud F, O'Sullivan N, Cipollini G, Coia V, Samadelli M, Engstrand L, Linz B, Moritz RL, Grimm R, Krause J, Nebel A, Moodley Y, Rattei T, and Zink A
- Subjects
- Asia, Chromosome Mapping, DNA, Bacterial genetics, DNA, Bacterial isolation & purification, Europe, Helicobacter pylori isolation & purification, Human Migration, Humans, Ice Cover microbiology, Mummies microbiology, Phylogeny, Phylogeography, Sequence Analysis, DNA, Genome, Bacterial genetics, Helicobacter Infections microbiology, Helicobacter pylori genetics, Hybridization, Genetic, Stomach microbiology
- Abstract
The stomach bacterium Helicobacter pylori is one of the most prevalent human pathogens. It has dispersed globally with its human host, resulting in a distinct phylogeographic pattern that can be used to reconstruct both recent and ancient human migrations. The extant European population of H. pylori is known to be a hybrid between Asian and African bacteria, but there exist different hypotheses about when and where the hybridization took place, reflecting the complex demographic history of Europeans. Here, we present a 5300-year-old H. pylori genome from a European Copper Age glacier mummy. The "Iceman" H. pylori is a nearly pure representative of the bacterial population of Asian origin that existed in Europe before hybridization, suggesting that the African population arrived in Europe within the past few thousand years., (Copyright © 2016, American Association for the Advancement of Science.)
- Published
- 2016
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