1. Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia.
- Author
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Yoon JW, Kim E, Jeong N, Kang M, Kim HS, Lee S, Yoon HJ, Kim SG, Na E, Yang H, Park JH, Yang SY, Lin SK, Zhu X, Xiang YT, Sim K, Tan CH, Grover S, Avasthi A, Kallivayalil RA, Maramis MM, Chee KY, Pariwatcharakul P, Oo T, Kato TA, Javed A, Chong MY, Sartorius N, Shinfuku N, Park J, and Park SC
- Subjects
- Humans, Adult, Male, Female, Middle Aged, Asia, Depressive Disorder, Treatment-Resistant drug therapy, Depressive Disorder, Treatment-Resistant diagnosis, Suicide, Attempted statistics & numerical data, Antimanic Agents therapeutic use, Antidepressive Agents therapeutic use, Depressive Disorder, Major drug therapy, Depressive Disorder, Major diagnosis, Depressive Disorder, Major epidemiology, Young Adult, Suicidal Ideation
- Abstract
Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers., Competing Interests: Declaration of Competing Interest Seon-Cheol Park, an editorial board member of the Asian Journal of Psychiatry, was not involved in the evaluation of or decision to publish this article., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2024
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