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Mineralization processes in the Tell-Atlas of North Africa coincided with magmatism, extension, and lithospheric rejuvenation during the middle to late Miocene. This review examines the lead isotope compositions and Pb-Pb age dating of ore deposits in the region to elucidate the sources and timing of mineralization events. The data reveal a predominantly radiogenic signature in the ores, indicating that the primary component is from a crustal source, with a contribution from the mantle. Pb-Pb age dating suggests the ranges of mineralization ages, with late Miocene events being particularly significant, coinciding with proposed sub-continental mantle delamination following subduction of the African lithosphere. In this context, polymetallic mineralizations formed related to felsic magmatism, hydrothermalism driven by extensional faults, resulting in the formation of Mississippi Valley-Type, and Sedimentary exhalative deposits within associated semi-grabens and diapirism. The correlation between orogenic extensional collapse, magmatism, and mineralization underscores the importance of understanding the specific geological context of ore formation. The detachment of subducted slabs and subsequent influx of hot asthenosphere play pivotal roles in creating conducive conditions for mineralization. This study sheds light on the intricate interplay between tectonic mechanisms, mantle-crust interactions, and mineralization events in the Tell-Atlas, offering insights for further exploration in the region. [ABSTRACT FROM AUTHOR]