9 results on '"Butler L."'
Search Results
2. Arsenic-induced neurotoxicity in patients with acute promyelocytic leukaemia.
- Author
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Loh Z, Ashby M, Van Veldhuizen E, Li W, Chee A, Aung W, Lavrukhina Y, Mason G, Pelly T, Nedumannil R, Kosciejew S, Mokoonlall M, Lim J, Calov G, Butler L, Hillebrand P, Beekman A, Rathnasekara GK, Raj S, Zhang C, Yao Y, Iland H, and Grigg A
- Subjects
- Humans, Male, Female, Middle Aged, Adult, Retrospective Studies, Aged, Obesity complications, Australia epidemiology, Arsenic adverse effects, Arsenic toxicity, Young Adult, Adolescent, Aged, 80 and over, Leukemia, Promyelocytic, Acute drug therapy, Arsenic Trioxide adverse effects, Arsenic Trioxide administration & dosage, Arsenic Trioxide therapeutic use, Neurotoxicity Syndromes etiology, Neurotoxicity Syndromes epidemiology
- Abstract
Arsenic trioxide is an essential component of therapy for acute promyelocytic leukaemia (APL) and is currently dosed on actual body weight with no upper limit. Arsenic-induced neurotoxicity is a well-recognised complication; however, there is uncertainty about its relationship to arsenic dose and obesity. We conducted a large multicentre retrospective study of 487 patients with APL treated with arsenic-based therapy across 23 sites in Australia from 2008 to 2023. The primary outcome was incidence of neurotoxicity, and secondary outcomes included relationship of neurotoxicity to obesity and cumulative arsenic dose. Any-grade neurotoxicity occurred in 113 (23%) patients, predominantly peripheral neuropathy (91%). Most events were grade 1-2 severity (85%), with grade 3 events in 12% and grade 4-5 in 3%. The incidence of neurotoxicity increased with BMI (non-obese: 16%, obesity class I: 25%, obesity class II-III: 41%; p < 0.001). On univariable analysis, obesity class I (OR 1.81, p = 0.036), obesity class II-III (OR 3.93, p < 0.001), weight >100 kg (OR 2.72, p < 0.001), daily arsenic trioxide dose >15 mg (OR 5.05, p < 0.001) and cumulative induction dose >500 mg (OR 3.95, p < 0.001) were all significantly associated with neurotoxicity. Obesity class II-III and induction dose >500 mg remained significant on multivariable analysis. Our study highlights the strong association between BMI, arsenic trioxide dose and neurotoxicity. Pre-emptive dose reductions should be considered for obese patients receiving high doses of arsenic., (© 2024 British Society for Haematology and John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
3. Evaluation of the impact of National Breast Cancer Foundation-funded research.
- Author
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Donovan C, Butler L, Butt AJ, Jones TH, and Hanney SR
- Subjects
- Australia, Biomedical Research statistics & numerical data, Capacity Building economics, Capacity Building statistics & numerical data, Career Mobility, Cost-Benefit Analysis, Education, Graduate statistics & numerical data, Female, Health Policy, Health Services Research economics, Health Services Research statistics & numerical data, Humans, Program Evaluation, Research Personnel economics, Research Personnel education, Research Personnel statistics & numerical data, Research Support as Topic statistics & numerical data, Translational Research, Biomedical economics, Translational Research, Biomedical statistics & numerical data, Bibliometrics, Biomedical Research economics, Breast Neoplasms diagnosis, Breast Neoplasms economics, Breast Neoplasms therapy, Foundations statistics & numerical data
- Abstract
Objective: To evaluate the impact of the National Breast Cancer Foundation's (NBCF's) research investment., Design and Participants: Surveys based on the Payback Framework were sent to chief investigators involved in research funded by the NBCF during 1995-2012; a bibliometric analysis of NBCF-funded publications in 2006-2010 was conducted; and a purposive, stratified sample of case studies was obtained., Main Outcome Measures: Research impact on knowledge production, the research system, informing policy, product development and broader health and economic benefits., Results: Of 242 surveys sent, 153 (63%) were returned. The average impact of journals in which NBCF publications appeared was double that of world publications. Seventy surveys (46%) reported career progression, and 185 higher degrees were obtained or expected, including 121 PhDs. One hundred and one grants (66%) produced tools that built capacity across the research system, and research teams leveraged an additional $1.40 in funding for every dollar invested. Fifteen applied grants and one basic grant impacted on policy. Ten basic and four applied grants led to the development of drugs, prognostic tools or diagnostic technologies. Twenty applied and two basic grants led to changes in practice and behaviour of health care staff, consumers and the public, with further impacts anticipated. Case studies provided illustrations of high impact., Conclusions: NBCF's strategy of investing in a mixed portfolio of research areas and mechanisms encouraged a broad range of impacts across all Payback categories. The impacts from basic research tended to focus on knowledge production and drug development; while applied research generated greater impacts within the other Payback categories. The funding of shared infrastructure stimulated impact across the research system.
- Published
- 2014
- Full Text
- View/download PDF
4. Effects of nutrient and lime additions in mine site rehabilitation strategies on the accumulation of antimony and arsenic by native Australian plants.
- Author
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Wilson SC, Leech CD, Butler L, Lisle L, Ashley PM, and Lockwood PV
- Subjects
- Acacia metabolism, Australia, Biodegradation, Environmental, Calcium Compounds pharmacology, Cynodon metabolism, Eucalyptus metabolism, Hazardous Waste Sites, Mining, Nitrogen pharmacology, Oxides pharmacology, Phosphorus pharmacology, Plant Roots metabolism, Plant Shoots metabolism, Plant Stems metabolism, Poa metabolism, Potassium pharmacology, Sulfur pharmacology, Antimony metabolism, Arsenic metabolism, Soil Pollutants metabolism
- Abstract
The effects of nutrient and lime additions on antimony (Sb) and arsenic (As) accumulation by native Australian and naturalised plants growing in two contaminated mine site soils (2,735 mg kg(-1) and 4,517 mg kg(-1) Sb; 826 mg kg(-1) and 1606 As mgkg(-1)) was investigated using a glasshouse pot experiment. The results indicated an increase in soil solution concentrations with nutrient addition in both soils and also with nutrient+lime addition for Sb in one soil. Metalloid concentrations in plant roots were significantly greater than concentrations in above ground plant parts. The metalloid transfer to above ground plant parts from the roots and from the soil was, however, low (ratio of leaf concentration/soil concentration≪1) for all species studied. Eucalyptus michaeliana was the most successful at colonisation with lowest metalloid transfer to above ground plant parts. Addition of nutrients and nutrients+lime to soils, in general, increased plant metalloid accumulation. Relative As accumulation was greater than that of Sb. All the plant species studied were suitable for consideration in the mine soil phytostabilisation strategies but lime additions should be limited and longer term trials also recommended., (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Published
- 2013
- Full Text
- View/download PDF
5. NHMRC grant applications: a comparison of "track record" scores allocated by grant assessors with bibliometric analysis of publications.
- Author
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Nicol MB, Henadeera K, and Butler L
- Subjects
- Australia, Biomedical Research, Random Allocation, Bibliometrics, Financing, Organized, Organizations, Nonprofit, Publications
- Abstract
Objectives: To investigate the correlation between the publication "track record" score of applicants for National Health and Medical Research Council (NHMRC) project grants and bibliometric measures of the same publication output; and to compare the publication outputs of recipients of NHMRC program grants with those of recipients under other NHMRC grant schemes., Design: For a 15% random sample of 2000 and 2001 project grant applications, applicants' publication track record scores (assigned by grant assessors) were compared with bibliometric data relating to publications issued in the previous 6 years. Bibliometric measures included total publications, total citations, and citations per publication. The program grants scheme underwent a major revision in 2001 to better support broadly based collaborative research programs. For all successful 2001 and 2002 program grant applications, a citation analysis was undertaken, and the results were compared with citation data on NHMRC grant recipients from other funding schemes., Main Outcome Measure: Correlation between publication track record scores and bibliometric indicators., Results: The correlation between mean project-grant track record scores and all bibliometric indicators was poor and below statistically significant levels. Recipients of program grants had a strong citation record compared with recipients under other NHMRC funding schemes., Conclusion: The poor correlation between track record scores and bibliometric measures for project grant applications suggests that factors other than publication history may influence the assignment of track record scores.
- Published
- 2007
- Full Text
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6. The returns from cardiovascular research: the impact of the National Heart Foundation of Australia's investment.
- Author
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Clay MA, Donovan C, Butler L, and Oldenburg BF
- Subjects
- Australia, Fellowships and Scholarships statistics & numerical data, Humans, Biomedical Research economics, Fellowships and Scholarships economics, Heart Diseases, Research Support as Topic statistics & numerical data, Voluntary Health Agencies economics
- Abstract
Objective: To evaluate the outcomes of the research investment of the National Heart Foundation of Australia (NHF)., Design and Setting: The NHF Research Evaluation Working Group was established in 2002 to oversee evaluation of research funding and outcomes data collected over a 5-year period. The evaluation included a bibliometric analysis conducted by the Research Evaluation and Policy Project at the Australian National University., Outcome Measures: Level and leverage of research funding; funding levels across the disciplines of biomedical, clinical, and public health research; and visibility and knowledge impact of NHF-supported research in international cardiovascular journals., Results: The NHF's investment in research increased by 27% from 2001 to 2005. This increase resulted from leveraged support for fellowships and scholarships of $1.5 million over this period, and $2.2 million from the pharmaceutical industry. There was an increase in fellowship and scholarship funding from 26% in 2001 to 46% in 2005. There was a 75% increase in the funding allocated to public health research from 2002 to 2004. NHF-funded research publications were found in high impact journals at levels above Australian and world averages, but received fewer citations than expected based on citation rates for all similar articles., Conclusions: The NHF has been successful in implementing a policy to allocate 50% of its research funding to people and 50% to projects. This strategy has led to an increase in funding support for public health research. NHF-funded research has performed very well in terms of knowledge impact. The NHF is now well placed to strategically fund relevant research in the future.
- Published
- 2006
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7. Mapping Australia's basic research in the medical and health sciences.
- Author
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Bourke P and Butler L
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- Australia, Authorship, Databases, Factual, Humans, Societies, Scientific, Abstracting and Indexing, Academies and Institutes, Health Services Research organization & administration, Publishing organization & administration, Research organization & administration
- Abstract
The Institute for Scientific Information indexes most of the major international basic research journals in science in the Science Citation Index (SCI). Australia's presence in the medical and health sciences journals in the SCI and the citations its published research receives in these journals show that Australia's basic medical research has high international "visibility". Mapping the source of the most highly "visible" Australian medical research articles shows high impact research coming from several different sectors (research institutes, universities, hospitals, etc.), but with a concentration in the member institutions of the Australian Association of Medical Research Institutes (AAMRI). Published research from the AAMRI is cited at a rate two-thirds higher than the Australian average for medical and health sciences.
- Published
- 1997
- Full Text
- View/download PDF
8. Administration and co-ordination of services and facilities for the aged in Murray Bridge.
- Author
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Butler L
- Subjects
- Aged, Australia, Humans, Organization and Administration, Geriatrics, Health Facilities supply & distribution, Health Services supply & distribution
- Published
- 1976
9. Retrieval of the critically ill in South Australia: a coordinated approach.
- Author
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Gilligan JE, McCleave D, Nicholson B, Lafsky P, Jacquier D, Fuller W, Allen TH, Phillips G, Butler L, and Stableford V
- Subjects
- Adolescent, Adult, Aircraft, Ambulances, Australia, Child, Preschool, Communication, Costs and Cost Analysis, Emergencies, Emergency Medicine instrumentation, Female, Humans, Male, Middle Aged, Pregnancy, Critical Care, Transportation of Patients
- Abstract
A system is described for the stabilization and evacuation of the critically ill in South Australia, with a discussion of experience in 278 patients. The integration of activities of peripheral medical practitioners, major teaching hospitals, and the ambulance transport authority (St John Ambulance Council) is paramount. Modes of communication are by "urgent line" telephone and radio. Advanced life-support equipment is portable, may be placed in any ambulance vehicle, and is used and maintained principally by the staff of intensive care units. The design characteristics of a suitable road vehicle and fixed-wing aircraft are considered, with emphasis on dimensions for the particular needs of advanced life-support. The cost of transporting such a patient is approximately two-thirds of an average bed day cost in a public hospital, plus the basic ambulance charge. The number of patients who need such measures is 0.2% of the total number of patients carried by ambulance per annum.
- Published
- 1977
- Full Text
- View/download PDF
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