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RTQA Gafchromic, radiochromic film is assessed for its radiation energy dependence in photon beams ranging from superficial to megavoltage energies. RTQA radiochromic film has uses in radiation quality assurance procedures due to its auto development and visualisation properties. These properties allow for immediate comparison of x-ray alignment and coincidence not available with radiographic films. Results show that the RTQA film produces an energy dependant darkening to x-rays which results in x-ray energies of 69 keV photon equivalent (150 kVp) to produce 2.14 times the optical density to dose ratio of a 6MV x-ray beam. The following dose ratio's (normalized to 1 at 150 kVp) provide the same net optical density change for RTQA film. 1.47-50 kVp : 1.21-75 kVp : 1.09-100 kVp : 1.01-125 kVp: 1.00-150 kVp : 1.03-200 kVp : 1.07-250 kVp : 2.14-6 MVp : 2.14 10 MVp. Although the film is not designed to be used as a quantitative measure of radiation it is still useful to know its energy response at differing x-ray energies to expose the film to the appropriate dose to provide optimal darkening characteristics for a given QA test at the appropriate energy. Our results have shown that a 0.3 optical density change with RTQA film provides a colour change level useable for accurate alignment procedures

The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an alpha,beta-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.