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Darwin Harbour, Northern Territory, Australia, is a semi diurnal macro-tidal embayment that is situated in a cyclone prone area. The tidal variations range up to 8 m with a mean tidal range of 3.7 m. The coastal area consists of mangrove fringes, sandy beaches, tidal flats, rocky shore platforms and coastal cliffs. The main morphological changes are movement of the sandbars and erosion of beaches and coastal cliffs. Sea level rise due to climate change and more intense cyclones and storm surges may exacerbate these processes with detrimental impacts on the coast and the adjacent city, particularly when occurring at high tide. To assist with coastal erosion management, a greater understanding of morphological changes is required. A two-dimensional depth averaged finite-element hydrodynamic model (RMA-2), coupled with a sediment transport model (RMA-11) from Resource Modelling Associates, have been used to deduce the sources and spatial patterns of sand erosion and deposition in the harbour. Geochemical analysis is also used to characterize the sand source(s). This paper presents hydrodynamic simulations focusing on culturally and recreationally significant beaches in Fannie Bay. Simulations indicate that the Cullen Bay sandbar is an indirect sand source replenishing Fannie Bay beaches. Respective geochemical results also show similar Rare Earth Element contents of the sand in the area. Considering the fast pace of development in and around Darwin Harbour, this study is essential in providing a fundamental understanding of coastal processes and to assist coastal and shoreline management in a tropical estuary. [ABSTRACT FROM AUTHOR]

Conventional G-banded karyotype is an essential tool for detecting chromosomal variants in patients undergoing fertility evaluation. In Australia, 15 cells are traditionally analysed or counted, to enhance detection of mosaic chromosomal variants. However, this protocol is not backed by clinical evidence. This study aims to assess the test performance of an abbreviated 5-cell karyotype analysis protocol in adult patients undergoing fertility evaluation. A retrospective review of 53,293 blood karyotype tests, performed between 2019 and 2023, was conducted on a patient cohort primarily referred by reproductive endocrinology specialists. There were 513 variants reported in this cohort. Low level mosaic variants, where the variant was observed in less than 40% of cells, were reported in 13 cases, or one in 4,100 patients. Due to reduced sensitivity for low level mosaic variants, a 5-cell protocol is estimated to have a test sensitivity of 97.3% and a negative predictive value of 99.97%. A decision-making flowchart is proposed and we show that additional chromosome analysis and/or counts would be triggered in fewer than one in 10 cases using a 5-cell protocol, whilst remaining appropriate for detecting clinically significant mosaicism. A 5-cell karyotype analysis protocol therefore maintains analytical and clinical validity in adult patients undergoing fertility-related blood karyotyping. Future research is recommended to validate these findings across laboratories and to explore their application to other clinical contexts., (Copyright © 2024 Royal College of Pathologists of Australasia. Published by Elsevier B.V. All rights reserved.)