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1. Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii.

Author

Li H, Gilchrist CLM, Lacey HJ, Crombie A, Vuong D, Pitt JI, Lacey E, Chooi YH, and Piggott AM

Subjects
Anti-Bacterial Agents biosynthesis, Aspergillus metabolism, Australia, Isomerism, Mannose chemistry, Molecular Structure, Multigene Family, Oxidation-Reduction, Pyrrolidines chemistry, Secondary Metabolism, Anti-Bacterial Agents chemical synthesis, Aspergillus chemistry, Heterocyclic Compounds, 2-Ring chemistry
Abstract

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

Published
2019
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