1. Clinical and dermoscopic characteristics of melanomas on nonfacial chronically sun-damaged skin.
- Author
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Jaimes N, Marghoob AA, Rabinovitz H, Braun RP, Cameron A, Rosendahl C, Canning G, and Keir J
- Subjects
- Adult, Age Distribution, Aged, Australia epidemiology, Cohort Studies, Early Detection of Cancer methods, Female, Humans, Hutchinson's Melanotic Freckle epidemiology, Hutchinson's Melanotic Freckle etiology, Incidence, Male, Melanoma epidemiology, Melanoma etiology, Middle Aged, Neoplasm Invasiveness pathology, Neoplasm Staging, Prognosis, Retrospective Studies, Risk Assessment, Sex Distribution, Skin Neoplasms epidemiology, Skin Neoplasms etiology, Ultraviolet Rays adverse effects, Dermoscopy methods, Hutchinson's Melanotic Freckle pathology, Melanoma pathology, Skin Neoplasms pathology, Sunlight adverse effects
- Abstract
Background: Melanomas on chronically sun-damaged skin (CSDS) can be difficult to identify and often manifest morphologic features that overlap with benign lesions., Objective: We describe and analyze the clinical and dermoscopic characteristics of melanomas on nonfacial CSDS., Methods: Melanoma cases on nonfacial CSDS were retrospectively identified from the biopsy specimen logs of 6 melanoma clinics. Clinical and dermoscopic images were combined into 1 database. Demographics, clinical, dermoscopic, and histopathologic information were analyzed. Descriptive frequencies were calculated., Results: One hundred eighty-six cases met the inclusion criteria: 142 melanomas in situ (76%) and 39 invasive (21%; mean thickness, 0.49 mm). Lentigo maligna was the most common histopathologic subtype (n = 76; 40.9%). The most frequent dermoscopic structures were granularity (n = 126; 67.7%) and angulated lines (n = 82; 44%). Vascular structures were more frequent in invasive melanomas (56% vs 12% of in situ melanomas). Most manifested 1 of 3 dermoscopic patterns: patchy peripheral pigmented islands, angulated lines, and tan structureless with granularity pattern., Limitations: This was a retrospective study, and evaluators were not blinded to the diagnosis. In addition, interobserver concordance and sensitivity and specificity for dermoscopic structures were not evaluated., Conclusion: Outlier lesions manifesting dermoscopic structures, such as granularity, angulated lines, or vessels and any of the 3 described dermoscopic patterns should raise suspicion for melanoma., (Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
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