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Despite having to perform the same occupational tasks as full-time soldiers, part-time soldiers may have lower levels of physical conditioning and report higher rates of injury per unit exposure to active service. The purpose of this study was to profile the leading body site of injury occurring in part-time soldiers to inform injury prevention strategies. Injury data from the Australian Army Reserve (ARES) spanning a two-year period were obtained from the Department of Defence Workplace Health, Safety, Compensation and Reporting database pertaining to locations, nature, mechanisms, and the activity being performed at the time of injury. Among the 1434 injuries reported by ARES personnel, the knee was the most common injury site ( n = 228, 16%). Soft tissue injury due to trauma or unknown causes was the most common nature of knee injury ( n = 177, 78%). Combat training was the most common activity being performed when soft tissue injuries occurred at the knee ( n = 73, 42%), with physical training the second most common ( n = 51, 30%), due to muscular stress ( n = 36, 71%) and falls ( n = 8, 16%). Targeted intrinsic and extrinsic approaches to injury minimization strategies for soft tissue knee injuries during combat and physical training should be designed.