1. The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the Arctic bryozoan Tegella cf. spitzbergensis.
- Author
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Tadesse M, Tabudravu JN, Jaspars M, Strøm MB, Hansen E, Andersen JH, Kristiansen PE, and Haug T
- Subjects
- Animals, Anti-Bacterial Agents chemistry, Antifungal Agents chemistry, Antifungal Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Australia, Candida albicans drug effects, Drug Screening Assays, Antitumor, Escherichia coli drug effects, Humans, Indoles chemistry, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Pseudomonas aeruginosa drug effects, Staphylococcus aureus drug effects, Anti-Bacterial Agents isolation & purification, Anti-Bacterial Agents pharmacology, Antifungal Agents isolation & purification, Antineoplastic Agents isolation & purification, Bryozoa chemistry, Indoles isolation & purification, Indoles pharmacology
- Abstract
The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.
- Published
- 2011
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