Search

The purpose of this naturalistic observation study was to observe, in a natural setting, the actions of attendees at educational professional development conferences. In doing so, it was hoped that numerous behaviors could be observed that would indicate a level or extent of engagement or disengagement within presentations. It was found that the observed sample was often communicating with others or looking around the room while the presentation was unfolding. Fiddling with objects was common since arriving at a presentation takes time to settle. Overall, the audience was mostly distracted and not engaged which would logically diminish the utility of the professional development.

This paper discusses the concept of "primal landscapes" as a way of conceptualising the interactions between children and the environments they grow up in. The paper discusses this concept drawing on empirical research conducted in the field of human geography on how people learn about their environments. The research employed a qualitative inductive methodology and involved interviews with 40 participants across two rural case studies in north Queensland, Australia. Based on these case studies, the paper discusses three main findings for environmental education. First, the paper draws attention to the importance of experiential learning during the "concrete operations" phase of childhood development. Second, the paper emphasises the importance of involving elders and family in environmental education. Third, the paper shows that opportunities for adult place-based environmental education include festivals and reflecting on natural hazards, such as floods and fires. (Contains 1 table.)

The presence of salinity and sodicity in the root zone can limit root development and impact crop yield. Topsoil constraints are likely to have the greatest impact on crop growth early in the growing season, when plant roots are still shallow. Later in the growing season, subsoil constraints may have a greater impact as roots reach deeper into the soil. This study investigated whether different patterns of spatial variation in crop growth would be evident in remote sensing data captured from different stages of the growing season, with the aim of providing a means of indicating whether soil constraints in the topsoil and in the subsoil might be impacting crop growth. If a topsoil constraint is impacting growth, we might expect its effects to show through a negative correlation between the soil constraint and the early-season vegetation index. However, we would not expect to observe the impact of a subsoil constraint until later in the season (when roots have reached the constraint). To test the results from the analysis of remote sensing data, we used soil data from five fields from across Australia's northern grains-growing region. We used these data to assess soil constraint severity and correlations between the soil constraints and enhanced vegetation index (EVI). The results of the study were inconclusive, and it was difficult to identify a dominant soil constraint with a clear relationship to crop growth. The soil data were also insufficient to draw conclusions about the depths of any dominant soil constraints. Furthermore, there was a lot of subjectivity in the interpretations of the correlations between remote sensing and soil data. The study also investigated the consistency of the spatial variation in EVI over multiple years, but the results were still inconclusive. In conclusion, this study highlights the challenges of using remote sensing data to diagnose soil constraints in agricultural settings. While remote sensing can provide useful insights into crop growth, interpreting these data and drawing meaningful conclusions about soil constraints requires further research and development. [ABSTRACT FROM AUTHOR]

Soil constraints limit plant growth and grain yield in Australia's grain-cropping regions, with the nature of the impact dependent on climate. In seasons with low in-crop (short for "during the crop growing season") rainfall, soil constraints can reduce yield by limiting soil water infiltration, storage, and crop water uptake. Conversely, soil constraints can exacerbate waterlogging in seasons with high in-crop rainfall. When average in-crop rainfall is experienced, soil constraints may only have a limited impact on yields. To investigate the relationship between climate and the impact of soil constraints on crop growth, long-term time series yield information is crucial but often not available. Vegetation indices calculated from remote-sensing imagery provide a useful proxy for yield data and offer the advantages of consistent spatial coverage and long history, which are vital for assessing patterns of spatial variation that repeat over many years. This study aimed to use an index of crop growth based on the enhanced vegetation index (EVI) to assess whether and how the within-field spatial variation of crop growth differed between years with different climates (dry, moderate, and wet years, as classified based on in-crop rainfall). Five fields from the grain-growing region of eastern Australia were selected and used to assess the consistency of the spatial variation of the index for years in the same in-crop rainfall category. For four of the five fields, no evidence of patterns of climate-dependent spatial variation was found, while for the other field, there was marginal evidence of spatial variation attributable to wet years. The correlation between measured data on soil sodicity (a soil constraint that might be expected to impact crop growth most in wetter years) and average EVI was investigated for this field. The results showed a stronger negative correlation between average EVI and sodicity in wet years than in dry years, suggesting that sodicity—through its impacts on soil structure and water movement—might be a driver of the spatial variation of crop growth in wet years for this field. Our results suggest that although there may be cases when climate-dependent within-field spatial variation of crop growth is detectable through remote-sensing data (through the multi-year consistency of the within-field variation), we should not expect this to be evident for fields as a matter of course. [ABSTRACT FROM AUTHOR]

Background: In animal, epidemiological, and human challenge studies, a pre-existing T-cell response to internal proteins of influenza A has been associated with improved virological and disease outcomes. The aim of this study was to assess whether inducing additional responses to conserved CD4 and CD8 T-cell antigens provides added benefit to standard influenza vaccination.Methods: We designed a phase 2b, randomised, placebo-controlled, double-blind trial of a recombinant viral-vectored vaccine (modified vaccinia Ankara expressing virus nucleoprotein and matrix protein 1; MVA-NP+M1), which has been shown to induce both CD4 and CD8 T cells, at eight outpatient clinical trial sites in Australia over two consecutive influenza seasons. We recruited non-immunosuppressed adults (≥18 years) who had received the 2019 quadrivalent influenza vaccine (QIV) vaccine within 28 days before study enrolment and randomisation (day 0). Participants were randomly assigned (1:1) according to a computer-generated random sequence to receive one dose of 1·5 × 108 plaque-forming units of MVA-NP+M1 or saline (placebo) intramuscularly. Randomisation was stratified by age (<65 years or ≥65 years). The patients and trial assessors were masked to treatment assignment. During the subsequent influenza seasons, participants with symptoms related to respiratory illness or influenza-like illness were to attend the clinic within 72 h of symptom onset for two nasal swabs for influenza testing by quantitative RT-PCR. The primary endpoint was the incidence rate of laboratory-confirmed influenza in the intention-to-treat (ITT) population. Safety (solicited adverse events within 7 days and unsolicited adverse events within 28 days after study vaccination, and serious adverse events for the study duration) was assessed in all randomly assigned participants who received at least one vaccination (according to the treatment received). The trial is registered with ClinicalTrials.gov, NCT03880474.Findings: Between April 2 and June 14, 2019, 2152 adults were randomly allocated and received MVA-NP+M1 (n=1077) or placebo (n=1075), comprising the efficacy (ITT) analysis set. Participants were followed up throughout the 2019 Australia influenza season (May 1 to Oct 15, 2019). 419 (19·5%) of 2152 participants were aged 65 years or older. The incidence of laboratory-confirmed influenza did not differ between the MVA-NP+M1 group (35 of 1077 participants; 3·25% [95% CI 2·31-4·44]) and the placebo group (23 of 1075; 2·14% [1·39-3·14]; Fisher's exact p=0·14). 23 severe solicited local injection site reactions were reported in 13 (0·6%) of 2152 participants, 22 of which were reported in the MVA-NP + M1 group (in 12 [1·1%] participants). 100 severe systemic events were reported in 45 (4·2%) MVA-NP + M1 recipients, and 20 were reported in 14 (1·3%) placebo recipients. Three unsolicited grade 3 events in three participants (two headache and one nausea, all in the MVA-NP+M1 group) were deemed vaccine related. 21 serious adverse events were reported in 18 (1·7%) of 1077 participants in the MVA-NP+M1 group and 25 serious adverse events were reported in 22 (2·0%) of 1075 participants in the placebo group; none were considered vaccine related. The trial was stopped after one season for futility on the recommendation of the data monitoring committee.Interpretation: MVA-NP+M1 was well tolerated with no vaccine-associated serious adverse events. A vaccine designed to induce moderate T-cell responses to the cross-reactive internal proteins of influenza A did not lead to improved incidence when given within 28 days after standard QIV immunisation. A greater magnitude of T-cell response with a different vaccine or regimen, or localisation in the lungs via alternative delivery, such as intranasal or aerosol, might be successful and require further investigation.Funding: Vaccitech. [ABSTRACT FROM AUTHOR]

Background: This study aimed to describe the clinical outcomes of total pancreatectomy with islet autotransplantation (TP‐IAT) in Australia. Methods: Individuals selected for TP‐IAT surgery according to the Minnesota Criteria (Appendix) without evidence of diabetes were evaluated including time to transplantation from pancreatectomy, islet numbers infused and post‐transplantation HbA1c, C‐peptide, total daily insulin and analgesic requirement. Results: Sixteen individuals underwent TP‐IAT from Australia and New Zealand between 2010 and 2020. Two recipients are deceased. The median islet equivalents/kg infused was 4244 (interquartile range (IQR) 2290–7300). The median C‐peptide 1 month post‐TP‐IAT was 384 (IQR 210–579) pmol/L and at median 29.5 (IQR 14.5–46.5) months from transplant was 395 (IQR 139–862) pmol/L. Insulin independence was achieved in eight of 15 (53.3%) surviving recipients. A higher islet equivalents transplanted was most strongly associated with the likelihood of insulin independence (P < 0.05). Of the 15 surviving recipients, 14 demonstrated substantial reduction in analgesic requirement. Conclusion: The TP‐IAT programme in Australia has been a successful new therapy for the management of individuals with chronic pancreatitis including hereditary forms refractory to medical treatment to improve pain management with 50% insulin independence rates. This study describes the Australian experience of total pancreatectomy with islet autotransplantation. Sixteen individuals underwent total pancreatectomy with islet autotransplantation in Australia from 2010 to 2020. [ABSTRACT FROM AUTHOR]

Background: Acute Appendicitis is the most common surgical presentation within Australia. Despite the increasing use of radiological investigations to aid clinical diagnosis, many appendectomies result in a histologically normal appendix. This study examines the histological negative appendicectomy rate (NAR) in a metropolitan hospital and determine factors associated with a negative appendicectomy (NA). Methods: Patients who underwent emergency appendicectomy for suspected acute appendicitis at Logan Hospital, Australia, between February 2016 and March 2019 inclusive were included. Clinicopathologic and imaging variables were analysed for associations with NA. Results: A total of 1241 patients underwent emergency appendicectomy of which 121 patients (9.8%) had a NA. The NAR for clinical diagnosis alone (no imaging) was 9.9%, 14.5% for ultrasonography alone and computed tomography scan alone was 4.9%. Univariate analysis revealed age <27 years (P < 0.001), absence of hypertension (P = 0.008), symptoms >48 hours (P < 0.001), absence of leucocytosis (P < 0.001), undergoing ultrasonography only (P < 0.001), undergoing computed tomography scan only (P < 0.001), macroscopically normal appendix (P < 0.001) and time to operation >24 hours (P < 0.001) were associated with NA. Multivariate analysis identified symptoms >48 h at presentation (odds ratio (OR) 1.98, 95% confidence interval (CI) 1.20–3.24; P = 0.007), absence of leucocytosis (OR 2.41, 95% CI 1.52–3.81; P < 0.001) and macroscopically normal appendix (OR 5.70, 95% CI 3.49–9.33; P < 0.001) to be associated with a NA. Conclusion: The NAR reported is lowest in an Australian institution. The identified predictors of NA will be useful in identifying patients who would truly benefit from an appendicectomy versus those would have a higher rate of NA who may be suitable to be treated non‐operatively to be spared the unnecessary morbidity of surgery. A low negative appendicectomy rate may be achieved by careful clinical assessment by elucidating a patients signs and symptom duration with blood test results assessing for leucocytosis. [ABSTRACT FROM AUTHOR]

Nephropathy is a known complication of the Fontan circulation, but its determinants have not been identified and patient outcomes are also still unknown. The Australia and New Zealand Fontan Registry was used to identify those who underwent Fontan operation before and survived beyond 16-years-old with an intact Fontan circulation. Serum creatinine values were collected for each patient between 16 and 25 years and at recent follow-up. The Modification of Diet in Renal Disease (MDRD) equation was used to calculate eGFR. Patient outcomes were obtained from the Registry. Fontan failure was defined as death, transplantation, plastic bronchitis, protein losing enteropathy, Fontan takedown and NYHA class III-IV. Serum creatinine measurements were available for 328 patients. Renal dysfunction was defined as eGFR <90 mL/min/1.72m2. Renal dysfunction was present in 67/328 (20%) and 3/328 (1%) patients had an eGFR <60 mL/min/1.72m2. The 10-year survival and 10-year freedom from death and transplantation were the same, 96% (95% CI: 0.9–1) for those with renal dysfunction, and 89% (0.83–0.95; p = 0.1) and 87% (95% CI: 0.81–0.94; p = 0.05) for patients without dysfunction. The 10-year freedom from failure were also similar, 83% (95% CI: 0.70–0.97) for those without renal dysfunction vs 80% (95% CI: 0.74–0.89; p = 0.84). There was no change in mean eGFR for the renal dysfunction group over a mean of 8 ± 5.5 years. By the time they reach adulthood, 20% of patients with a Fontan circulation have renal dysfunction by eGFR calculation. Over the course of one decade, Fontan-associated nephropathy appears well tolerated. • 20% of young adults with a Fontan circulation have evidence of nephropathy. • No hypoplastic left heart syndrome patients were found to have nephropathy. • Nephropathy appears to be well tolerated over a follow-up period of a decade. • True predictors of Fontan-associated nephropathy remain unclear at this time. [ABSTRACT FROM AUTHOR]

Objectives Fitness industry professionals (personal trainers, group instructors) may have a role in health promotion, particularly when working with subgroups with known health risks (e.g. older adults, obese). The aim of this study is to examine fitness professionals' level of interest in engaging with high-risk populations. Study design Cross-sectional evaluation of a national survey. Methods In 2014, 9100 Australian registered exercise professionals were invited to complete an online survey. Respondents reported their level of interest in engaging with nine health-risk population subgroups. A multivariable logistic regression analysis assessed the odds of being classified as having a 'low level' of interest in training high health-risk subgroups, adjusting for demographic and fitness industry-related factors. Results Of 1185 respondents (aged 17-72 years), 31.1% reported having a 'high level' of interest in training high health-risk subgroups. The highest level of interest was among 'obese clients' and 'adults (18-64 years) with chronic health conditions'. In the adjusted analysis, males (odds ratio [OR], 1.55, 95% confidence interval [CI]: 1.06-2.25) and those in urban settings (OR, 2.26, 95% CI: 1.54-3.37) were more likely to have a 'low level' of interest. Conclusions Fitness professionals have a modest level of interest in training high health-risk subgroups. In addition to the development of strategies to increase interest, research should examine whether fitness professionals are able to safely prescribe exercise to high health-risk subgroups. [ABSTRACT FROM AUTHOR]

Unconventional shale plays have received marked attention over the last five years because of their economic potential for hydrocarbon generation, and yet they are amongst the least understood of all clastic sedimentary rock systems. The Cooper Basin is one of the largest Gondwana intracratonic basins in Australia, extending from northern South Australia into south-western Queensland and covering approximately 130,000 km 2 . The basin is may be prospective for shale gas, particularly within the lacustrine shales of the Permian Murteree and Roseneath formations. This study investigates lithological characteristics of these two units in relation to reservoir evaluation. Core samples representing the Dirkala-02 and Moomba-46 wells were used for petrographic analysis. A combination of wireline log analysis, thin section petrography, X-ray diffraction and pyrolysis analysis was used to define and characterize four distinct lithofacies facies within the Roseneath and Murteree shales: siliceous mudstone, organic siliceous mudstone, calcareous siliceous mudstone, and silty siliceous mudstone. The siliceous mudstone and organic siliceous mudstone are the most common. Diagenetic siderite occurs in all four lithofacies. A conceptual depositional model is developed for deposition of the Roseneath and Murteree shales. Wireline-log cross plots were interpreted and utilized in the construction of electrofacies. The study was concentrated on the northern portion of the basin between the Nappameri and Patchawarra Troughs in order to understand the nature of lithofacies and variability in reservoir architecture, which was controlled by relative lake level fluctuation. The results of this study will aid in the evaluation of shale gas potential for this portion of the basin, as well as a better understanding of shale gas opportunities in the Cooper Basin more generally. [ABSTRACT FROM AUTHOR]

Identifying the documentary and archaeological indications of torture, punishment, discipline and imprisonment are key factors in addressing the ways in which society exerts its control over the individual; particularly the non-conformist, the criminal, the indentured and the enslaved. Expressions of forced labour control are quite common in the archaeological record, at places such as large institutions, plantations, mining towns and industrial sites. But there are distinct differences between criminal imprisonment and racial enslavement, which become evident when one examines the permeability and persistence of physical and social boundaries. The ways in which Euro- Australian and Aboriginal prisoners were treated in nineteenth century Western Australia gave rise to a system in which physical boundaries were more or less permeable for one group, but not the other. Although it was outlawed by the British Parliament just a few years after the Swan River Colony was established, both formal and informal types of incipient slavery seem to have persisted in the guise of forced incarceration, indentured servitude and illicit abductions. This was, in a way, reminiscent of the enslavement of native North Americans in the sixteenth to eighteenth centuries. Several examples are provided to illustrate these ideas. [ABSTRACT FROM AUTHOR]

As mining expands throughout the world, a growing body of literature is focusing on the relationship between mining and well-being in locations where resource extraction occurs. Although many topics such as employment and migration have been researched, the impacts of mining on income inequality have received less attention from scholars. Income inequality is a highly debated topic and the Gini coefficient (GC) one of the most popular indicators used to measure and discuss it. In this paper we estimate GCs for all sub-State regions of Australia and analyse their changes during the ‘mining boom decade’ (2001–11) across mining and non-mining regions. Our results show that, on average, income inequality increased by around 4.8 per cent in mining regions, compared to 8.7 per cent in the average non-mining region. However, the results also show important variation in changes of GC across mining regions, suggesting that the industry is likely to affect the distribution of local incomes in different ways. The method we propose to estimate GCs for regional areas and the results obtained across mining and non-mining regions provide important insights for future research and for regional policy makers, especially those concerned with the socio-economic impacts of industries such as mining across regions. [ABSTRACT FROM AUTHOR]

The article focuses on orbital cellulitis is a potentially sight and life-threatening condition with acute onset of often non-specific clinical features and it is an infectious inflammation of the soft tissues of the orbit posterior to the orbital septum and be caused by bacteria, fungi or protozoa. Topics include the Chandler's staging is a diagnostic tool used to categorise orbital, and the specialist treatment centres depend on timely referrals to ensure appropriate transfer of patients.

• Persistently poor-growing areas in fields can indicate a soil constraint. • Remote-sensing data with a long history can reveal these areas within fields. • ConstraintID is an online tool to help grains growers reveal persistent patterns. • It can be used to guide soil sampling and help interpret the resulting soil data. • It links soil data with critical values of soil constraints to different crops. Soil constraints, such as soil sodicity, salinity and acidity, are one cause of yield loss for grain growers globally. A first step towards reducing the associated yield gap is the identification of the area affected and the soil constraint/s responsible for the yield loss. Within a single field, persistent spatial variation of crop growth that repeats year after year is likely due to some form of soil constraint. Vegetation indices derived from satellite imagery can provide a valuable alternative to yield maps for assessing these persistent patterns. The variation identified from remote-sensing data can be compared with soil data from the field to help identify which soil constraints are potentially causing yield differences. This application note describes ConstraintID (www.constraintid.com.au), a web-based software tool that makes it easy for growers to use and interact with remote-sensing data to (1) reveal the persistent long-term variation of crop growth within their fields, (2) devise targeted soil sampling plans and (3) interpret the resulting soil data in view of critical values for certain soil constraints. [ABSTRACT FROM AUTHOR]

Complementing the scarce economic literature about local impacts of energy extraction booms, this paper empirically investigates economic outcomes related to the new coal seam gas ( CSG) industry located across southern Queensland. This Australian state has seen an unprecedented inflow of investments into the extraction of this previously unexploited unconventional natural gas over the last decade. We analyse census data to study income and employment effects associated with the CSG boom, exploiting the quasi-experimental conditions provided by CSG extraction areas (treatment regions) and regions without this development (control regions). Findings show that treatment regions have higher income growth than control areas during 2001-2011 for families residing locally and for individuals present on census night. Employment in the mining sector also shows higher growth as has non-mining employment in some areas. We include comparisons between CSG areas with no major mining history (the Surat basin) and CSG areas where mining was important before the CSG boom (the Bowen basin), to better understand boom effects in areas with different initial mining industry importance in their economies. Local job multipliers are also analysed for Surat basin CSG areas, where positive impacts (job spillovers) are restricted to construction and professional services jobs, while agricultural jobs have decreased. [ABSTRACT FROM AUTHOR]

Social learning continues to attract the attention of researchers in natural resource management, yet little published research focuses specifically on social learning time frames. This article aims to redress this knowledge gap through presenting insights from a longitudinal study in Australia. The study involved four interview rounds from 2004 to 2009 with landholders taking part in a program focused on managing dryland salinity. The results demonstrate that participants were initially frustrated by the slow pace of social learning. Evidence of social learning occurred after approximately 1 year, but was initially restricted to an increased understanding of the problem without improved knowledge to address it. This knowledge emerged during the third year of the program. Based on the findings presented here, comparable social learning programs should consider a minimum of 3 years to allow enough time to develop new knowledge for tackling complex problems. [ABSTRACT FROM PUBLISHER]

Questions over the role of mining in the Australian economy and society have gained increasing public scrutiny in recent years. In this paper we consider whether the role of mining in Australian society has changed with the recent mining boom. The paper draws attention to four key areas. The first is the economics of mining, where a rise in commodity values has made mining more profitable. Mining now dominates Australian exports more than in previous booms. The second area is the scale of mining operations, which have grown substantially, reflecting unprecedented investment. The third area is the degree to which the effects of resource extraction extend to surrounding areas and distant urban centres through long distance commuting. Finally, we consider the centrality of the mining sector in public life: attention to mining in the media and encroachment on other land uses, and we look for evidence of changes in public acceptance of the sector. In conclusion we argue that the role of the mining sector in Australian society and economy has indeed changed. The changes in terms of trade and the scale of mining have made the resource sector so important in Australia that increased impact in public life is unavoidable. [ABSTRACT FROM AUTHOR]

Objectives: To examine temporal trends in the incidence and recurrence of hospitalised coronary heart disease (CHD), cerebrovascular disease (CeVD) and peripheral arterial disease (PAD) separately and combined, and by the history of all forms of atherothrombotic disease (ATD). Design: Population-based longitudinal data linkage study. Setting Western Australia. Participants: All patients aged 35e84 years hospitalised in Western Australia for CHD, CeVD or PAD from 2000 to 2007. Main Outcome Measures: Age-standardised incidence and recurrence rates of CHD, CeVD and PAD stratified by ATD history, sex and age. Results: 107 576 events (65.9% men) were identified; 70% of all admissions were for CHD. In patients without a history of any ATD, incidence rates declined significantly in all groups, although the reduction in incident CHD in women was marginal (0.7%/year, 95% CI 1.5 to +0.1%). The largest annual reductions in incidence rates were for PAD (men, 6.4%/year, 95% CI 7.7 to 5.0%; women, 5.4%/year, 95% CI 7.2 to 3.6%) and CeVD in women (4.0%/year, 95% CI 5.0 to 3.0%). Falls in overall recurrence rates were greatest for CeVD (men, 3.2%/year, 95% CI 4.7 to 1.6%; women 4.6%/year, 95% CI 6.4 to 2.7%). Trends across all categories of polyvascular ATD were generally downward, although not all changes were statistically significant. Conclusion: The incidence and recurrence rates of hospitalised ATD have decreased over time, including in patients with disease involving multiple vascular territories. This implies that primary and secondary prevention strategies have been broadly effective. However, high absolute rates of recurrence and limited reduction in 35e54-year-old individuals highlight patient groups to target to reduce further the burden of ATD. [ABSTRACT FROM AUTHOR]

A key question for rural regions concerns the extent to which they can shape their own future. Addressing this issue in any given location inevitably involves defining regional aspirations in the face of global pressures. To navigate this nexus of endogenous and exogenous factors, we emphasise the role of informed dialogue in place-specific contexts, where both the possible contributions of science and the values held by local participants are openly discussed. In this article we present an overview of the theoretical underpinnings of this action research approach, followed by a case study application in Apollo Bay, Victoria, Australia. This case study made use of qualitative scenarios to underpin discussion regarding the future of the region, in particular reconsideration of the focus on township expansion for survival. We suggest that evaluation has a strong role to play in a dialogic research process. Evaluation can bring insights from participatory scenario development to the surface and can encourage the identification of factors that enabled and disabled learning. The development of our approach raised a number of issues that are discussed here yet could be fruitfully researched further. The first is the extent to which place, in terms of amenity, identity and resources, materially shapes the options for regional development. The second is the role institutions operating at multiple scales play in addressing those options. [ABSTRACT FROM AUTHOR]

Mining activity has been a significant driver of export growth as well as income and employment in parts of regional Australia. However, while income growth is an economic benefit, the high incomes associated with the mining sector may also lead to greater inequality. This paper describes an empirical analysis of mining activity and income inequality in regional Australia. The Gini coefficient (a measure of inequality) for personal income is found to be significantly associated with levels of mining employment. However, this relationship is not linear. Rather, income inequality initially increases with mining activity, before decreasing at medium to high levels of mining employment, following a Kuznets curve pattern. Segregating data for men and women reveals very different patterns. Among men, inequality initially increases as mining employment in a region increases, but then sharply decreases; at high levels of mining activity, income inequality among men is lower than is typically observed in non-mining areas. Among women, income inequality increases with mining activity throughout its range. This suggests that income inequality is most likely to be a problem in locales with intermediate levels of mining activity and that it affects men and women quite differently. [ABSTRACT FROM AUTHOR]

On average, Australia is a dry continent with many competing uses for water. Hence, there is an urgent need to know actual evapotranspiration (ETa) patterns across wide areas of agricultural and natural ecosystems, as opposed to just point measurements of ETa. The Australian Government has tasked the science agencies with operationally developing monthly and annual estimates of ETa and other hydrological variables, and with forecasting water availability over periods of days to decades, as part of its national water assessment programme. To meet these needs, Australian researchers have become leaders in developing large-area methods for estimating ETa at regional and continental scales. Ground methods include meteorological models, eddy covariance towers, sap flow sensors and catchment water balance models. Remote sensing methods use thermal infrared, mid infrared and/or vegetation indices usually combined with meteorological data to estimate ETa. Ground and remote sensing ETa estimates are assimilated into the Australian Water Resource Assessment, which issues annual estimates of the state of the continental water balance for policy and planning purposes. The best ETa models are estimated to have an error or uncertainty of 10% to 20% in Australia. Developments in Australian ETa research over the past 20 years are reviewed, and sources of error and uncertainty in current methods and models are discussed. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Remote dryland regions are characterised by sparse populations and socially marginalised voices which pose particular challenges to natural resource management. This paper considers the issue of how to achieve community engagement in regions with these characteristics. In doing so, the paper contributes to an expanding international research agenda focusing on the distinct characteristics of arid and semi-arid regions under the heading of 'dryland syndrome'. The paper draws on government liaison officer and local community perspectives of successful engagement in the case-study region of Lake Eyre Basin, Australia. The results demonstrate that widely recognised characteristics of successful engagement are required but insufficient for genuine engagement in remote dryland regions. In addition to building trust through community ownership, being inclusive, effective communication, and adequate resources, genuine community engagement in drylands also requires respecting the extreme conditions and extraordinary variability of these areas. Residents of dryland regions seek genuine engagement yet engage opportunistically when seasons are conducive and when tangible outcomes are visible. [ABSTRACT FROM AUTHOR]

Recent dramatic rises in the price of diesel fuel have resulted in the questionable viability of sectors of the Australian commercial fishing industry. Many fishing vessels currently operating in the fleet are over 20 years old and operate in a way that is inefficient in terms of the energy input (combustible fuels) in contrast with the useful energy output (catch). Combined with the global need to reduce greenhouse gas emissions there is a clear need to introduce new efficiencies into fishing vessel operations. This paper reports on the development of an energy audit method for fishing vessels, based on similar systems for land-based industries. It enables the analysis of individual vessels to be made and allows the assessment of their energy usage and current level of efficiency. A sample energy audit has been conducted for an Australian fishing vessel that leads to recommendations for improved efficiencies to combat present and possible future fuel cost increases. [ABSTRACT FROM AUTHOR]

Carbonaceous microbe-like features preserved within a local chert unit of the 3.5 Ga old Apex Basalt in Western Australia may represent some of the oldest evidence of life on Earth. However, the biogenicity of these putative microfossils has been called into question, primarily because the sample collection locality is a black, carbon-rich, brecciated chert dike representing an Archean submarine hydrothermal spring, suggesting a formation via an abiotic organic synthesis mechanism. Here we describe the macromolecular hydrocarbon structure, carbon bonding, functional group chemistry, and biotic element abundance of carbonaceous matter associated with these filamentous features. These characteristics are similar to those of biogenic kerogen from the ca. 1.9 Ga old Gunflint Formation. Although an abiotic origin cannot be entirely ruled out, it is unlikely that known abiotic synthesis mechanisms could recreate both the structural and compositional complexity of this ancient carbonaceous matter. Thus, we find that a biogenic origin for this material is more likely, implying that the Apex microbelike features represent authentic biogenic organic matter. [ABSTRACT FROM AUTHOR]

Knowledge of the manner in which genetic variation within a tree species affects associated communities and ecosystem processes across its entire range is important for understanding how geographic mosaics of genetic interactions might develop and support different communities. While numerous studies have investigated the community and ecosystem consequences of genetic variation at the hybrid cross type or genotype level within a species, none has investigated the community-level effects of intraspecific genetic variation across the geographic range of a widespread species. This is the scale at which geographic mosaics of coevolution are hypothesized to exist. Studies at this level are particularly important for foundation tree species, which typically support numerous microbial, fungal, plant, and animal communities. We studied genetic variation across eight geographical races. of the forest tree Eucalyptus globulus representing its natural distribution across southeastern Australia. The study was conducted in a 15-year-old common garden trial based on families derived from single-tree open-pollinated seed collections from the wild. Neutral molecular genetic variation within E. globulus was also assessed and compared with genetic divergence in the phenotypic and community traits. Three major findings emerged. First, we found significant genetically based, hierarchical variation in associated communities corresponding to geographical races of E. globulus and families within races. Second, divergence in foliar communities at the racial level was associated with genetically based divergence in specific leaf morphological and chemical traits that have known defensive functions. Third, significant positive correlations between canopy community dissimilarity and both neutral molecular genetic and leaf quantitative genetic dissimilarity at the race level supported a genetic similarity rule. Our results argue that genetic variation within foundation tree species has the potential to be a significant driver of the geographical mosaics of variation typical of forest communities, which could have important ecological and evolutionary implications. [ABSTRACT FROM AUTHOR]

Conventional approaches to evaluation of environmental programs have tended to limit themselves to restricted measures of program effectiveness. This paper shows how a social learning approach can be incorporated into evaluating public environmental programs. A social learning approach is particularly suited to complex environmental challenges which are inherently difficult to understand, predict, and manage, thus complicating the evaluation process. The paper presents an Australian case study of dryland salinity management where there are major knowledge barriers impeding conventional management techniques. The research presented in this paper focused on evaluating a public demonstration program to track its impact through its design, implementation, and monitoring phases. The paper shows that, by incorporating social learning principles and practices, program evaluation can promote collective action, critical reflection, and increased knowledge to underpin improved environmental management. [ABSTRACT FROM AUTHOR]

Copyright of Canadian Journal of Forest Research is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Blessed with a great diversity of natural and cultural assets, the countries of Latin America should be thriving as international tourist destinations. The reality is, however, that the region is a long way from reaching its full potential. This paper reports the findings of a survey that investigated the reasons why Australian travel agents and tour operators thought that Latin America was receiving so few tourists from Australia. The main finding of the study was that there is a lack of knowledge among travel agents about the Latin American region. Many of them could only identify a limited number of tourist attractions in the region. While the study has an Australian focus, the authors suggest that the barriers underlying the lack of international demand for Latin American tourism products are similar to those that exist in other potential source markets. [ABSTRACT FROM PUBLISHER]

Copyright of Atmosphere - Ocean (Canadian Meteorological & Oceanographic Society) is the property of Canadian Meteorological & Oceanographic Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This article focuses on the technology and its relation with the size of multi-national corporations. One major explanation of the foreign direct-investment process suggests that firms exploit some form of "technological superiority" in their direct international operations. Johnson asserts that maximizing rent on knowledge is the crux of the foreign investment process. The exploitation of technological advantage in a firm's international operations is well documented in the product-cycle account of international trade and investment, technological advantage, arising from successful industrial innovation, is initially embodied in internationally-traded goods and later, in response to a variety of possible market changes, the process is transferred to direct operations in those markets previously serviced by trade. Operating subsidiaries in various locations contributes to the MNCs total level of profits. The decision to sell products or services via direct, subsidiary operations will be the result of a number of factors. In particular, conditions within the firm and within particular markets such as, for example, trade barriers, will influence the decision to operate a subsidiary or export to that market.

This paper reports the results of a study, based on a questionnaire survey, designed to provide information about these issues associated with the technology dimension of foreign direct investment in the Australian manufacturing sector. The questionnaire was designed to provide data on a number of aspects of actual technology characteristics of foreign-direct-investment subsidiaries in Australian manufacturing, as welt as form the basis for some limited statistical tests of various hypotheses associated with the technology dimension of foreign direct investment. In particular, information was collected on the following: (a) The extent of R&D undertaken by subsidiaries in Australia and the influence of several characteristics of foreign subsidiaries on the level of R&D and the type of R&D undertaken. (b) The source of funds for R&D undertaken by subsidiaries, and the role of the Commonwealth Government's Industrial Research and Development (I.R.&D.) grant scheme in fostering domestic R&D by foreign subsidiaries. The extent to which I.R.&D funds have been directed to modifying overseas technology. (c) The channels of access to new overseas technology used by subsidiaries and the terms of access to affiliate and non-affiliate technology. One major issue is the differences, if any, in the restrictions imposed by affiliates, on the one hand, and non-affiliated firms on the other hand, on the use of imported technology. The extent of outward technology flows to both affiliated and non-affiliated firms overseas, and the importance of technology-swap arrangements. (d) The extent of export activity by foreign subsidiaries, including the role of restrictions on exporting attached to technology agreements encompassed by the general restrictions in (c), above. In particular, an important issue is whether export restrictions are more prevalent with affiliate or with non-affiliate technology agreements. [ABSTRACT FROM AUTHOR]

The paper reports the results of a survey of 393 Australian firms regarding their access to overseas-sourced technology and the extent and nature of restrictions attached to technology transfer. The results suggest that Australian firms are not generally subject to widespread binding restrictions attached to technology sourced from overseas. Furthermore, with the exception of restrictions on technology re-licensing, there is no significant difference between foreign- and domestically-owned firms in the incidence of restrictions. [ABSTRACT FROM AUTHOR]

Examines the structural and functional nature of social support networks for intravenous or injecting drug users (IDUs) in Sydney. Implications for HIV/AIDS services; Research findings.

Climate change is a significant challenge for policy makers, planners and communities. While adaptation responses are generally recognised to be place-based, policy processes on adaptation often reside with central (state or national) governments that may be remote from regional communities. In this paper, we contribute to the literature regarding how diverse regional communities engage with planning and policy for climate adaptation, which is important for successful implementation. We adopt a social network analysis (SNA) approach that enables an exploration of the interaction of community networks with policy information. There are limited empirical studies of information sharing about climate adaptation policy through community knowledge networks. One previous study, located in coastal New South Wales, Australia, mapped the community's knowledge acquisition and diffusion to reveal the underlying network structures that influenced policy engagement pathways. However, further studies are needed to determine how the features of community networks may change with local context (e.g., coastal versus inland). This paper extends previous studies to compare and contrast adaptation knowledge networks in three NSW communities: Shoalhaven (the original coastal study site), Bega (coastal) and Orange (inland). Findings suggest that the presence of a natural resource-dependent industry, local geographies and boundary spanners acting as network knowledge brokers are factors influencing community knowledge flows. The work further demonstrates the utility of SNA to measure knowledge networks that can inform government engagement and communication with communities on climate adaptation policy. [ABSTRACT FROM AUTHOR]

In the June, 1984 issue of this Journal, Cronin (1984) examines the effect of changes in the level of protection on the level of employment in the motor-vehicle sector, comparing his results with those of the IAC (1981)and myself(Parry, 1981). A reading of Cronin's paper can give a misleading impression of what was attempted in my study. This note seeks to clarify two major points about that study, and, in doing this, raises some questions about certain of the underlying assumptions in Cronin's analysis. [ABSTRACT FROM AUTHOR]

[ABSTRACT FROM AUTHOR]

Summary Objectives Predictive resting metabolic rate (RMR) equations in Australian populations are at least 10 years old, focused on males and do not commonly use overweight and obese weight categorisation. The aim of this study was to measure RMR via indirect calorimetry in overweight and obese Australian adults to develop population specific predictive equations and compare with other well-known international equations (Mifflin–St. Jeor, Owen and WHO/FAO/UNU). Methods Retrospective data from 278 participants (154 males, 124 females: 37% overweight, 63% obese) who had attended a weight management clinic were used to develop predictive RMR equations. These were then validated against another sample (from the same clinic) of 297 participants (150 males, 147 females: 47% overweight, 53% obese), and their accuracy compared with known standard equations. Results For the prediction sample, weight, BMI, resting VO 2 and measured RMR were significantly greater in the obese than overweight. Using the validation sample, the predictive equations met a ±10% of measured RMR criterion 42% (females), 41% (total sample) and 40% (males) of the time. Prediction accuracy was not improved by using specific overweight and obese weight category equations, or by applying the known standard equations from the literature. Conclusions In our sample of overweight and obese adults, RMR prediction to within ±10% of the measured value was only accurate ∼40% of the time, regardless of gender and weight classification. In clinical weight management settings direct measures of RMR should be made wherever possible. [ABSTRACT FROM AUTHOR]

Koolpinyah virus (KOOLV) isolated from healthy Australian cattle and Yata virus (YATV) isolated from a pool of Mansonia uniformis mosquitoes in the Central African Republic have been tentatively identified as rhabdoviruses. KOOLV was shown previously to be related antigenically to kotonkon virus, an ephemerovirus that has caused an ephemeral fever-like illness in cattle in Nigeria, but YATV failed to react antigenically with any other virus tested. Here we report the complete genome sequences of KOOLV (16,133 nt) and YATV (14,479 nt). Each has a complex genome organisation, with multiple genes, including a second non-structural glycoprotein (G NS ) gene and a viroporin (α1) gene, between the G and L genes as is characteristic of ephemeroviruses. Based on an analysis of genome organisation, sequence identity and cross-neutralisation, we demonstrate that both KOOLV and YATV should be classified as two new species in the genus Ephemerovirus . [ABSTRACT FROM AUTHOR]

• CMRSET evapotranspiration (ET a) parameterised for five remote sensing data products. • Its forthright implementation requires routinely available optical and climate data. • Daily ET a estimates can be obtained from 20 to 500 m including in standing water. • Calibrated against ET a at 30 flux towers in Australia in multiple climates/vegetation. • High accuracy in ET a estimates when compared with water balance at 638 catchments. Actual evapotranspiration (ET a) can be estimated using optical remote sensing and meteorological data. Herein we calibrated and applied the CMRSET (CSIRO MODIS Reflectance-based Scaling EvapoTranspiration) model at the continental scale in Australia using five remotely sensed data products with spatial resolutions ranging from 500 m (MODIS, VIIRS), 30 m (Landsat) to 20 m (Sentinel-2), and temporal frequencies ranging from daily (MODIS, VIIRS) to multi-days (Landsat and Sentinel-2). The five remotely sensed data products were used to compute a crop factor (k c) based on two vegetation indices which modify Priestley-Taylor potential evapotranspiration estimates (ET p ; calculated from nation-wide daily meteorological grids) to obtain ET a. CMRSET was calibrated using daily latent heat observations from 30 eddy covariance flux towers located across Australia, representing a wide variety of land covers and climates. To ensure that CMRSET adequately estimated open water evaporation, daily ET p estimates at six water sites were also added in the calibration network. The calibrated CMRSET model was able to estimate daily ET a observed at the flux towers with a relative Root Mean Squared Error (rRMSE)/coefficient of determination (R2) ranging between 0.15/0.96 (with Sentinel-2) to 0.26/0.93 (VIIRS). Additionally, we independently evaluated the performance of CMRSET by comparing the long-term (5 years or more) differences between mean annual precipitation and ET a with measured streamflow at 638 unimpaired catchments across Australia. The comparison showed a RMSE of 0.50 mm·d-1 (rRMSE of 0.26) and a R2 of 0.70. The CMRSET model performed better than or similarly when compared against two global ET a products based on MODIS optical and thermal data. Extending the suite of remotely sensed data products that CMRSET is calibrated with and using a network of sites located across vast climate and geographic ranges, means that CMRSET can now be used to estimate ET a at continental scales with multiple spatial resolutions and temporal frequencies. Compared to other available ET a products, CMRSET is more straightforward to operationalise, requires less data inputs, can capture ET a dynamics in areas with significant direct evaporation such as floodplains and lakes and does not require manual calibration to detect wet and dry pixels. [ABSTRACT FROM AUTHOR]

• We demonstrate flaws in the CMRSET implementation in Bretreger et al. (2020). • Actual evapotranspiration biases were because they used an incorrect Landsat band. • The calculation of GVMI should have used Landsat SWIR1 band instead of SWIR2. • CMRSET's suitability for irrigation monitoring is demonstrated via new experiments. • CMRSET evapotranspiration using the correct SWIR1 band did not show large biases. In a recent paper published in this journal, Bretreger et al. (2020) estimate irrigation water use from satellite remotely sensed estimates of actual evapotranspiration in five irrigated districts of the Murray-Darling Basin (southeast Australia). They used three models that scale crop reference evapotranspiration with vegetation indices acquired by recent Landsat satellites: (i) IrriSAT, (ii) Kamble and (iii) CMRSET. In their paper, irrigation water use computed with CMRSET generally overestimated observed irrigation water use, sometimes fivefold. Based on these results, Bretreger et al. (2020) discouraged the use of CMRSET for irrigation monitoring. In this comment, we reproduce the experiments in Bretreger et al. (2020), and demonstrate that their overestimation was because they used an incorrect Landsat band in their implementation of CMRSET. CMRSET was originally calibrated using both MODIS-derived Enhanced Vegetation Index (EVI) and Global Vegetation Moisture Index (GVMI). To calculate GVMI, a shortwave infrared (SWIR) band with a wavelength of ∼1.6 μm was used, which for MODIS is named SWIR2, and for Landsat is named SWIR1 (i.e., different sensors have different bands and a different number of bands and SWIR1 in MODIS has a wavelength of ∼1.2 μm). In their Landsat CMRSET implementation, Bretreger et al. (2020) computed GVMI using the Landsat SWIR2 band, which has a wavelength of ∼2.1 μm (see their Table 3). We show that CMRSET implemented with the Landsat SWIR1 band (i.e., with a wavelength of ∼1.6 μm, so being the correct Landsat band to calculate GVMI) yields similar results (both for temporal patterns and magnitude) when compared to the other two remote sensing actual evapotranspiration models in Bretreger et al. (2020). For the irrigation districts, these similar results meant that the mean water year (i.e., July to next June from 2010 to 2017) actual evapotranspiration mean absolute relative difference was 15.3% (with a 5.4%–26.5% range) and the water year irrigation water use mean absolute relative difference was 4.1% (with a 9.8%–18.9% range). Conversely, we show that a Landsat CMRSET implementation using the incorrect Landsat band for the calculation of GVMI (i.e., with a wavelength of ∼2.1 μm) led to a large overestimation agreeing with the CMRSET results reported by Bretreger et al. (2020), both for water year actual evapotranspiration (mean absolute relative difference of 64.6%, with a 51.1%–83.6% range) and irrigation water use (mean absolute relative difference of 44.1%, with a 31.4%–65.1% range). The use of the incorrect Landsat band means that the Bretreger et al. (2020) recommendation specific to their Landsat CMRSET implementation is invalid. A demonstration of Bretreger et al.'s (2020) incorrect Landsat CMRSET implementation and the correct one can be accessed at: https://jorgepena.users.earthengine.app/view/comment-on-bretreger-2020-joh-paper. Despite Bretreger et al.'s (2020) shortcomings in their implementation of the Landsat CMRSET actual evapotranspiration model, timely monitoring of irrigation water use via satellite remote sensing is required at Landsat resolutions (i.e., 30 m) or higher due to the heterogeneous nature of irrigation in most agricultural landscapes, and we applaud them for pursuing this line of research. [ABSTRACT FROM AUTHOR]

Background: Decreased levels of circulating ethanolamine plasmalogens [PE(P)], and a concurrent increase in phosphatidylethanolamine (PE) are consistently reported in various cardiometabolic conditions. Here we devised, a plasmalogen score (Pls Score) that mirrors a metabolic signal that encompasses the levels of PE(P) and PE and captures the natural variation in circulating plasmalogens and perturbations in their metabolism associated with disease, diet, and lifestyle., Methods: We utilised, plasma lipidomes from the Australian Obesity, Diabetes and Lifestyle study (AusDiab; n = 10,339, 55% women) a nationwide cohort, to devise the Pls Score and validated this in the Busselton Health Study (BHS; n = 4,492, 56% women, serum lipidome) and in a placebo-controlled crossover trial involving Shark Liver Oil (SLO) supplementation (n = 10, 100% men). We examined the association of the Pls Score with cardiometabolic risk factors, type 2 diabetes mellitus (T2DM), cardiovascular disease and all-cause mortality (over 17 years)., Findings: In a model, adjusted for age, sex and BMI, individuals in the top quintile of the Pls Score (Q5) relative to Q1 had an OR of 0.31 (95% CI 0.21-0.43), 0.39 (95% CI 0.25-0.61) and 0.42 (95% CI 0.30-0.57) for prevalent T2DM, incident T2DM and prevalent cardiovascular disease respectively, and a 34% lower mortality risk (HR = 0.66; 95% CI 0.56-0.78). Significant associations between diet and lifestyle habits and Pls Score exist and these were validated through dietary supplementation of SLO that resulted in a marked change in the Pls Score., Interpretation: The Pls Score as a measure that captures the natural variation in circulating plasmalogens, was not only inversely related to cardiometabolic risk and all-cause mortality but also associate with diet and lifestyle. Our results support the potential utility of the Pls Score as a biomarker for metabolic health and its responsiveness to dietary interventions. Further research is warranted to explore the underlying mechanisms and optimise the practical implementation of the Pls Score in clinical and population settings., Funding: National Health and Medical Research Council (NHMRC grant 233200), National Health and Medical Research Council of Australia (Project grant APP1101320), Health Promotion Foundation of Western Australia, and National Health and Medical Research Council of Australia Senior Research Fellowship (#1042095)., Competing Interests: Declaration of interests The Baker Institute has filed a provisional patent on the Plasmalogen Score. Application number: 2023900769; Title: Methods of assessing metabolic health. PJM consults for Juvenescence Ltd., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)

Background: Metabolic ageing biomarkers may capture the age-related shifts in metabolism, offering a precise representation of an individual's overall metabolic health., Methods: Utilising comprehensive lipidomic datasets from two large independent population cohorts in Australia (n = 14,833, including 6630 males, 8203 females), we employed different machine learning models, to predict age, and calculated metabolic age scores (mAge). Furthermore, we defined the difference between mAge and age, termed mAgeΔ, which allow us to identify individuals sharing similar age but differing in their metabolic health status., Findings: Upon stratification of the population into quintiles by mAgeΔ, we observed that participants in the top quintile group (Q5) were more likely to have cardiovascular disease (OR = 2.13, 95% CI = 1.62-2.83), had a 2.01-fold increased risk of 12-year incident cardiovascular events (HR = 2.01, 95% CI = 1.45-2.57), and a 1.56-fold increased risk of 17-year all-cause mortality (HR = 1.56, 95% CI = 1.34-1.79), relative to the individuals in the bottom quintile group (Q1). Survival analysis further revealed that men in the Q5 group faced the challenge of reaching a median survival rate due to cardiovascular events more than six years earlier and reaching a median survival rate due to all-cause mortality more than four years earlier than men in the Q1 group., Interpretation: Our findings demonstrate that the mAge score captures age-related metabolic changes, predicts health outcomes, and has the potential to identify individuals at increased risk of metabolic diseases., Funding: The specific funding of this article is provided in the acknowledgements section., Competing Interests: Declaration of interests The mAge score is included in a provisional patent, Application number 2023900769 (Methods of assessing metabolic health) and has been licenced to Trajan Scientific and Medical., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)

In health insurance markets with regulated competition, regulators face the challenge of preventing risk selection. This paper provides a framework for analyzing the scope (i.e., potential actions by insurers and consumers) and incentives for risk selection in such markets. Our approach consists of three steps. First, we describe four types of risk selection: (a) selection by consumers in and out of the market, (b) selection by consumers between high- and low-value plans, (c) selection by insurers via plan design, and (d) selection by insurers via other channels such as marketing, customer service, and supplementary insurance. In a second step, we develop a conceptual framework of how regulation and features of health insurance markets affect the scope and incentives for risk selection along these four dimensions. In a third step, we use this framework to compare nine health insurance markets with regulated competition in Australia, Europe, Israel, and the United States., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Aims: There are limited data on emergency catheter ablation (CA) for ventricular arrhythmia (VA) storm. We describe the feasibility and safety of performing emergency CA in an out-of-hours setting for VA storm refractory to medical therapy at 2 tertiary hospitals., Methods and Results: Twenty-five consecutive patients underwent out-of-hours (5pm-8am [weekday] or Friday 5pm-Monday 8am [weekend]) CA for VA storm refractory to anti-arrhythmic drugs and sedation. Baseline and procedural characteristics along with outcomes were compared to 91 consecutive patients undergoing weekday daytime-hours (8am-5pm) CA for VA storm. More patients undergoing out-of-hours CA had a left ventricular ejection fraction ≤35% (68% vs. 42%, P = 0.022), chronic kidney disease (60% vs. 20%, P < 0.001), and presented following a resuscitated out-of-hospital cardiac arrest (56% vs. 5%, P < 0.001), compared to the daytime-hours group. During median follow-up (377 [interquartile range 138-826] days), both groups experienced similar survival free from recurrent VA and VA storm. Survival free from cardiac transplant and/or mortality was lower in the out-of-hours group (44% vs. 81%, P = 0.007), but out-of-hours CA was not independently associated with increased cardiac transplant and/or mortality (hazard ratio 1.34, 95% confidence interval 0.61-2.96, P = 0.47). Of the 11 patients in the out-of-hours group who survived follow-up, VA-free survival was 91% and VA storm-free survival was 100% at 1-year after CA., Conclusion: Out-of-hours CA may occasionally be required to control VA storm and can be safe and efficacious in this scenario. During follow-up, cardiac transplant and/or mortality is common but undergoing out-of-hours CA was not predictive of this composite endpoint., Competing Interests: Conflict of interest: S.K. is supported by the NSW early-mid Career Fellowship. S.K. has received research grants from Abbott Medical and Biotronik; he has received honoraria from Biosense Webster, Abbott Medical, Biotronik, and Sanofi Aventis. All other authors have reported no other relationships relevant to the contents of this paper to disclose., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Background: Schistosomiasis is a disease that significantly impacts human health in the developing world. Effective diagnostics are urgently needed for improved control of this disease. CRISPR-based technology has rapidly accelerated the development of a revolutionary and powerful diagnostics platform, resulting in the advancement of a class of ultrasensitive, specific, cost-effective and portable diagnostics, typified by applications in COVID-19/cancer diagnosis., Methods: We developed CRISPR-based diagnostic platform SHERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) for the detection of Schistosoma japonicum and S. mansoni by combining recombinase polymerase amplification (RPA) with CRISPR-Cas13a detection, measured via fluorescent or colorimetric readouts. We evaluated SHERLOCK assays by using 150 faecal/serum samples collected from Schistosoma-infected ARC Swiss mice (female), and 189 human faecal/serum samples obtained from a S. japonicum-endemic area in the Philippines and a S. mansoni-endemic area in Uganda., Findings: The S. japonicum SHERLOCK assay achieved 93-100% concordance with gold-standard qPCR detection across all the samples. The S. mansoni SHERLOCK assay demonstrated higher sensitivity than qPCR and was able to detect infection in mouse serum as early as 3 weeks post-infection. In human samples, S. mansoni SHERLOCK had 100% sensitivity when compared to qPCR of faecal and serum samples., Interpretation: These schistosomiasis diagnostic assays demonstrate the potential of SHERLOCK/CRISPR-based diagnostics to provide highly accurate and field-friendly point-of-care tests that could provide the next generation of diagnostic and surveillance tools for parasitic neglected tropical diseases., Funding: Australian Infectious Diseases Research Centre seed grant (2022) and National Health and Medical Research Council (NHMRC) of Australia (APP1194462, APP2008433)., Competing Interests: Declaration of interests The authors declare no conflict of interest., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)