1. Antigenic and genomic diversity of central European respiratory syncytial virus strains.
- Author
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Lukic-Grlic A, Cane PA, Bace A, Pringle CR, Mlinaric-Galinovic G, and Popow-Kraupp T
- Subjects
- Antigens, Viral genetics, Austria epidemiology, Child, Croatia epidemiology, Disease Outbreaks, Genome, Viral, Genotype, Humans, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus, Human classification, Restriction Mapping, Antigenic Variation, Genetic Variation, Respiratory Syncytial Virus Infections virology, Respiratory Syncytial Virus, Human genetics, Respiratory Syncytial Virus, Human immunology
- Abstract
Thirty-two RSV strains recovered during the winter months of 1987/88 to 1993/94 from hospitalized children in Vienna, Austria and Zagreb, Croatia were analysed for antigenic and genetic variations. Twenty-nine of the 32 isolates investigated belonged to group A and 3 to group B, with the majority of infections caused by subgroup A1 (21 of 29). Restriction endonuclease mapping of PCR products derived from parts of the N and G gene of 18 group A strains identified 3 distinct lineages, very similar to those defined by analysis of recurrent epidemics in Birmingham, United Kingdom during the same period. Results of this study provide further information on the global pattern of RSV and show that very similar viruses are present simultaneously in widely separated areas.
- Published
- 1998
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