1. Primary resistance of Helicobacter pylori is still low in Southern Austria.
- Author
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Zollner-Schwetz, Ines, Leitner, Eva, Plieschnegger, Wolfgang, Semlitsch, Georg, Stepan, Vinzenz, Reiter, Lukas, Reicht, Gerhard, Mörth, Eduard, Pavek, Jörg, Parsché, Peter, Betterklieber, Christina, Atzmüller, Denise, Krause, Robert, and Högenauer, Christoph
- Subjects
HELICOBACTER pylori ,DRUG resistance in bacteria ,CLARITHROMYCIN ,MICROBIAL sensitivity tests ,METRONIDAZOLE - Abstract
Objectives We determined primary and secondary resistance rates of H. pylori in different regions of Austria and potential bacterial and host factors associated with resistance. Methods In a prospective multicentre study H. pylori was cultivated from biopsies and susceptibility testing was performed according to EUCAST. Resistance to clarithromycin and levofloxacin was determined by sequencing of the resistance-determining regions of 23S rRNA and gyrA genes. cagA , vacA and babA2 genotypes were determined. Results A total of 1266 patients were included. 178 isolates were cultured: 128 from patients without prior eradication therapy, 50 from patients after failed eradication. Primary resistance to clarithromycin, levofloxacin and metronidazole were 17.2%, 9.4% and 10.2%, respectively. Secondary resistance to clarithromycin, levofloxacin and metronidazole were 64%, 18% and 44%, respectively. Prior eradication was associated with a higher risk of clarithromycin as well as metronidazole resistance (OR = 8.1; 95% CI 3.8–17.1 and OR 5.7; 95% CI 2.5–13, respectively). Conclusion Primary resistance to both clarithromycin and levofloxacin was markedly lower in Southern Austria than recently reported. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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