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Background: Rhinosinusitis is inflammation of the sinuses, most commonly caused by a viral or bacterial infection or by allergic (or non-allergic; non-allergic could be due to infection). Fungal infections of the sinuses are uncommon and usually occur in individuals who are immunocompromised. However, recently, the occurrence of fungal sinusitis has increased in the immunocompetent population. Objective: Isolation and identification of fungi in Rhinosinusitis with antifungal sensitivity. Methods: The study was carried out on 112 patients who were suffering from rhinosinusitis, and then identification was done for the isolated fungi associated with rhinosinusitis 1-Specimens (Swabs (from nose and sinuses) and Water nasal washing) collection. 2-Direct microscopic exam. 3-Fungal isolation and diagnosis. 4-Anti-Fungal sensitivity test. 5-Patients (112 patient) were diagnosed by specialist Doctors according to the clinical symptoms and CT scan findings and biopsy. attending Al- Yarmouk Teaching hospital, and Baghdad Medical City. From February to June 2015. Results: The results showed that 38 (33.9%) patients were suffering from fungal infection in this study. The most common fungi isolated were Aspergillus spp. 18 (47.3%), followed by Rhizopus spp. 7 (18.4%), Trichophyton spp. 5 (13.1%), Penicillium spp. 3 (7.8%), yeast Candida spp. 2 (5.2%), Alternaria spp. 1 (2.6%), Cryptococcus neoformans 1 (2.6%) and Blastomyces dermatitidis 1 (2.6%). The antifungal of the most common three fungi isolated, which were (Aspergillus spp., Rhizopus spp., and Trichophyton spp.,) was determined for Amphotericin B, Griseofulvin and Ketoconazole. The result showed that tested fungi were sensitive to Amphotericin B and resistant to Griseofulvin and Ketoconazole. Conclusion: Fungal rhinosinusitis was moderate infection. Aspergillus spp., Rhizopus spp. and Trichophyton spp. were the most commonly fungus iolated from rhinosinusitis. They were sensitive to Amphotericin B and resistant to grisofulvin and ketoconazole. [ABSTRACT FROM AUTHOR]