1. Safety of ciprofloxacin in neonates with sepsis.
- Author
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Bonati, Maurizio, Pandolfini, Chiara, Kaguelidou, Florentia, Jacqz-Aigrain, Evelyne, Turner, Mark, and Choonara, Imti
- Subjects
SEPTICEMIA in children ,NEONATAL diseases ,CIPROFLOXACIN ,CEFOTAXIME ,ANTI-infective agents ,KLEBSIELLA pneumoniae - Abstract
The article examines studies on the use of ciprofloxacin in newborns with sepsis to evaluate its safety and efficacy. Studies were obtained from the MEDLINE and EMBASE databases and from the Cochrane Central Register of Controlled Trials. The studies considered were conducted between 1993 and 2004 in Turkey, Greece and Bangladesh. The first organism isolated from the blood of the neonates was Klebsiella pneumoniae. They were treated with ciprofloxacin and cefotaxime. No difference was seen in those treated with the drug and other antimicrobial agents.
- Published
- 2010
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