1. Epidemiology and antifungal susceptibilities of yeast isolates causing invasive infections across urban Beijing, China.
- Author
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Guo LN, Xiao M, Cao B, Qu F, Zhan YL, Hu YJ, Wang XR, Liang GW, Gu HT, Qi J, Yuan H, Min R, Wang FY, Liu LJ, Wang HB, Jiang W, Duan XG, Xu WJ, Yu YH, Su JR, Zhang JZ, Nong JQ, Liu SM, Li J, Liu JT, Yue ZG, Yang D, Guo J, Zhao R, Zhang YN, Yang XM, Liu XQ, Hsueh PR, and Xu YC
- Subjects
- Adolescent, Adult, Aged, Amphotericin B pharmacology, Antifungal Agents, Beijing epidemiology, Candida drug effects, Candida genetics, Candida isolation & purification, Candida pathogenicity, Candida albicans drug effects, Candida albicans genetics, Candida albicans isolation & purification, Candida albicans pathogenicity, Candida glabrata drug effects, Candida glabrata genetics, Candida glabrata isolation & purification, Candida glabrata pathogenicity, Candida parapsilosis drug effects, Candida parapsilosis genetics, Candida parapsilosis isolation & purification, Candida parapsilosis pathogenicity, Candida tropicalis drug effects, Candida tropicalis genetics, Candida tropicalis isolation & purification, Candida tropicalis pathogenicity, Candidemia epidemiology, Candidemia microbiology, Child, Child, Preschool, Drug Resistance, Fungal drug effects, Echinocandins pharmacology, Epidemiological Monitoring, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Sequence Analysis, DNA, Triazoles pharmacology, Yeasts genetics, Yeasts pathogenicity, Young Adult, Candidiasis, Invasive epidemiology, Candidiasis, Invasive microbiology, Microbial Sensitivity Tests methods, Yeasts drug effects, Yeasts isolation & purification
- Abstract
Aim: To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing., Materials & Methods: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method., Results: Candida (95.5%) remained the most common yeast species isolated; Candida albicans (38.8%) and Candida parapsilosis (22.6%) were the leading species of candidemia. Azole resistances were mainly observed in Candida glabrata and Candida tropicalis isolates., Conclusion: This study outlined the epidemiologic data of invasive yeast infections and highlighted the need for continuous monitoring of azole resistances among C. glabrata and C. tropicalis isolates in Beijing.
- Published
- 2017
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