1. Epidemiological characteristics of hand, foot, and mouth disease clusters during 2016-2020 in Beijing, China.
- Author
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Cui Y, Yang YN, Zheng RR, Xie MZ, Zhang WX, Chen LY, Du J, Yang Y, Xi L, Li H, Li HJ, and Lu QB
- Subjects
- Beijing epidemiology, Child, Child, Preschool, China epidemiology, Humans, Infant, Phylogeny, Enterovirus genetics, Hand, Foot and Mouth Disease epidemiology
- Abstract
Hand, foot, and mouth disease (HFMD) is an infectious disease that usually occurs in children under 5 years and is caused by a group of enteroviruses. This study aimed to investigate the epidemiological characteristics of HFMD clusters from 2016 to 2020 in Tongzhou, Beijing, and explored the genetic evolution of CV-A6. The HFMD case information came from the Information System of China Center for Disease Control and Prevention (CDC), as well as the clusters information verification and on-site investigation by Tongzhou CDC. ARIMA model was applied to forecast HFMD clusters in 2020. Totally 440 HFMD clusters were reported during 2016-2020. The large peak of the clusters occurred in April-July, followed by a smaller peak in October-November during 2016-2019. However, in 2020, the two peaks disappeared. The main site of HFMD clusters was childcare facilities (65.0%) and mostly occurred in urban areas (46.1%). The detection rate of CV-A6 was the highest (36.1%), and cases with CV-A6 infection had the highest proportion of fever. The phylogenetic analysis based on CV-A6 VP1 gene showed that the predominant strains mainly located in Group F during 2016-2017, while changed into Group A during 2018-2020. HFMD clusters presented seasonality, mainly located in childcare facilities and urban areas, and CV-A6 was the major causative agent. Targeted prevention and control measures should be taken to reduce HFMD clusters., (© 2022 Wiley Periodicals LLC.)
- Published
- 2022
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