1. Factors Associated with Low Admission Platelet Count in Adults with Acute Aortic Dissection.
- Author
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Li S, Lu J, Cheng W, Zhu J, and Jin M
- Subjects
- Acute Disease, Adolescent, Adult, Age Factors, Aged, Aortic Dissection diagnosis, Aortic Dissection surgery, Aortic Aneurysm diagnosis, Aortic Aneurysm surgery, Beijing, Biomarkers blood, Clinical Trials as Topic, Female, Fibrin Fibrinogen Degradation Products metabolism, Humans, Lipoproteins blood, Male, Middle Aged, Platelet Count, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Factors, Sex Factors, Time Factors, Young Adult, Aortic Dissection blood, Aortic Aneurysm blood, Blood Platelets metabolism, Patient Admission
- Abstract
Purpose: Platelets are crucial components of the coagulation processes, and low admission platelet count (PLC) is associated with adverse clinical outcomes in patients with Stanford type A acute aortic dissection (AAD)., Methods: A total of 130 consecutive patients undergoing Stanford type A AAD surgery in Beijing Anzhen Hospital were enrolled between January 2013 and July 2014. Preoperative clinical and laboratory data from patients were collected. Multiple regression analyses were used to determine the independent factors of low admission platelets., Results: Adjusted multiple regression analysis showed that age (β: -1.069, 95% confidence interval [CI]: -2.109, -0.029), sex (β: -29.973, 95% CI: -56.512, -3.433), tissue factor pathway inhibitor (TFPI; β: 0.197, 95% CI: 0.039, 0.354), fibrinogen degradation product (FDP) (β: -0.476, 95% CI: -0.879, -0.074), and attack time (β: 11.125, 95% CI: 7.963, 14.287) were significantly associated with admission PLC. Admission PLC increased with attack time up to the 3 days (β: 16.2, 95% CI: 12.1, 20.2)., Conclusions: We found that increasing age, male patients, patients with lower serum levels of TFPI and higher serum levels of FDP, and patients with a shorter attack time were significantly associated with lower PLC at admission. Moreover, the turning point of attack time is 3 days after the onset of dissection.
- Published
- 2019
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