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Aim: We constructed a multicentre cohort in China to analyse the differences in clinical characteristics, treatment strategies and prognoses between breast neuroendocrine carcinoma (NEC) and invasive ductal carcinoma (IDC) of the breast. Methods: All patients with early‐stage breast cancer who attended three hospitals in Beijing from 2000 to 2018 were included in the study. We used propensity score matching to make a 1:3 match between NEC and IDC. Results: After propensity score matching, 153 patients with IDC and 51 patients with NEC were analysed. Multivariate Cox regression showed that compared to patients with IDC, patients with NEC had a worse disease‐free survival (HR = 2.94, 95% CI: 1.69–5.12, p < 0.001). Conclusion: NEC patients have a worse disease‐free survival than IDC patients. [ABSTRACT FROM AUTHOR]

Background: In the current study, seizure semiology and potential predictive factors of seizure outcomes in glutamic acid decarboxylase antibody (GAD Ab)-associated neurological syndrome were investigated. Methods: In this study, 32 Chinese patients with GAD Ab-associated neurological syndrome who presented with seizures at Peking Union Medical College Hospital from January 2017 to October 2022 were reviewed; 30 had a follow-up duration of more than 1 year. Results: Among the 32 patients, 10 presented with epilepsy alone. Concomitant neurological syndromes were observed in 22 patients, including limbic encephalitis (n = 20), stiff-person syndrome (SPS, n = 1), and cerebellar ataxia (n = 1). Bilateral tonic–clonic seizures were observed in 21 patients (65.6%). Focal seizures occurred in 27 patients (84.4%); 17 had focal motor seizures and 18 focal non-motor seizures. Among 30 patients with long-term follow-up, 11 (36.7%) were seizure-free. Acute/subacute onset (p = 0.049) and comorbidity of limbic encephalitis with epilepsy (p = 0.023) led to better seizure outcomes. Patients with persistent epilepsy were more likely to have focal seizure (p = 0.003) and higher frequency of seizure (p = 0.001). Furthermore, these patients tended to have longer intervals from onset to immunomodulatory treatments. Early immunotherapy (within 6 months from onset) was administered in 81.8% of seizure-free patients but only in 42.1% of patients with persistent seizures. However, steroid and immunosuppressant duration did not differ in the two groups. Repeated serum GAD Ab tests during the follow-up showed no association with seizure outcomes. Conclusions: The seizure manifestations are diverse and variable. Approximately one third of patients achieved seizure remission during long-term follow-up. The type and frequency of seizures may influence the seizure outcomes. Early immunotherapy, especially within 6 months, may lead to better seizure outcomes. [ABSTRACT FROM AUTHOR]

• A health risk appraisal (HRA) system for urban heat island (UHI) was proposed. • Thermal environment changes in Beijing and health risks were identified. • A genetic algorithm simulated green space to suggest planning improvement measures. • Beijing UHI impacts respiratory diseases, cardiovascular diseases, and mental health. • Several suggestions were made to improve the thermal environment in Beijing. Urban heat islands (UHI) and global climate change pose serious threats to human health, making health risk appraisal of urban space as well as the planning and improvement of green space important research projrcts. Meteorological sites, satellite images, electronic maps, questionnaire survey data, statistical yearbooks, ArcGIS spatial analysis technology, MATLAB matrix analysis technology, remote sensing inversion, and ground-object extraction technology were used in this study to evaluate how changes in Beijing's urban thermal environment influence the health of residents. A genetic algorithm was used to optimize the simulation of green space, based on which, different measures were proposed to improve planning. The results show that areas of greater UHI impact on respiratory diseases, cardiovascular diseases and emotional health are mainly concentrated south of the North Second Ring Road in central Beijing. Furthermore, low-level influence areas are highly connected and clustered, while the high-level influence areas are distributed in clusters. The intelligent optimization and simulation of green space show that it exhibits a spatial distribution potentially with building green wedges and cooling corridors. Based on apprasial on health risk impact, analysis on health and climate zone, as well as optimization and simulation of green space, measures such as cooling nodes, urban blue axes, green rings, pergolas, and ventilation corridors are proposed to improve the comfort of urban living environments as well as reduce risks associated with health and environment. [ABSTRACT FROM AUTHOR]