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A recent report from Capital Medical University in Beijing, China, explores the mechanisms behind diabetic cardiomyopathy, a major complication of diabetes. The study focuses on small extracellular vesicles (sEVs) and their role in communication between cardiomyocytes and fibroblasts. The researchers found that diabetic cardiomyocyte-derived sEVs exacerbated cardiac fibrosis and worsened diastolic function, while normal cardiomyocyte-derived sEVs attenuated fibrosis and improved cardiac function. The study also identified miR-194-3p as a key molecule inhibiting fibroblast-to-myofibroblast conversion and blocking fibrosis. The findings suggest that restoring this system could be a potential therapy for diabetic cardiomyopathy. [Extracted from the article]

A recent study conducted at Peking Union Medical College Hospital in Beijing, China, explored the potential cardioprotective effects of canagliflozin, a drug used in the treatment of diabetes. The researchers found that canagliflozin improved mitochondrial function and activated a process called mitophagy, which helps maintain the integrity of mitochondria. These findings suggest that canagliflozin may be an effective treatment for diabetic cardiomyopathy, a condition that contributes to mortality in diabetic populations. The study highlights the potential of canagliflozin as a therapeutic option for individuals with diabetic cardiomyopathy. [Extracted from the article]

A new study conducted by researchers at Peking Union Medical College and Chinese Academy of Medical Sciences in Beijing, China, has found that ginsenoside Rg3, extracted from Panax notoginseng, has therapeutic effects on diabetes and heart diseases. The study focused on the mechanism of ginsenoside Rg3 on diabetic cardiomyopathy (DCM) and found that it directly binds to PPAR-g, improving adiponectin secretion and promoting adiponectin signaling. The researchers observed significant improvements in body weight, serum lipids, cardiac function, and pathological morphology in mice treated with ginsenoside Rg3. The study concludes that ginsenoside Rg3 could be a promising drug for treating diabetic cardiomyopathy. [Extracted from the article]

Microarray analysis of DCM rats' heart circular RNAs was performed and the highly species-conserved circRNA mitogen-activated protein kinase kinase kinase 5 (circMAP3K5) was identified, which participates in DCM processes. Keywords: Beijing; People's Republic of China; Asia; Apoptosis; Cardiology; Cardiomyocyte; Cardiomyopathies; Cardiovascular Diseases and Conditions; Cellular Physiology; Enzymes and Coenzymes; Genetics; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Kinase EN Beijing People's Republic of China Asia Apoptosis Cardiology Cardiomyocyte Cardiomyopathies Cardiovascular Diseases and Conditions Cellular Physiology Enzymes and Coenzymes Genetics Health and Medicine Heart Disease Heart Disorders and Diseases Kinase 772 772 1 11/06/23 20231106 NES 231106 2023 NOV 6 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Data detailed on Heart Disorders and Diseases - Cardiomyopathies have been presented. [Extracted from the article]