A recent study conducted at Peking Union Medical College Hospital in Beijing, China, explored the role of interleukin-22 (IL-22) in inflammation-related intestinal fibrosis. The researchers used various methods, including analyzing colon tissue samples from patients with Crohn's disease, conducting experiments on mice, and performing in vitro studies using cells. The findings suggested a potential positive correlation between IL-22 and colonic fibrosis, with possible mechanisms involving the influence on gut microbiota, pro-inflammatory pathways, immune cells, or pericytes. This research provides valuable insights into the understanding of cytokines and their impact on intestinal fibrosis. [Extracted from the article]