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This study aimed to translate into Chinese the Diabetes Care Profile (DCP), a measure of psychosocial factors and diabetes treatment, and to test the reliability and validity of the instrument within a Chinese population. The English version of the DCP was translated into Chinese following the standard translation methodology with consideration to cultural adaptation. The questionnaire was administered to 313 people with type 2 diabetes in an urban community in Beijing, China. Cronbach’s α coefficient was used to calculate reliabilities, which ranged from .55 to .86 on DCP subscales. Mean values on the DCP differed by diabetes treatment as expected and supports the construct validity of the DCP. The overall score on the DCP correlated well both with blood glucose levels and with a validated measure of a Chinese version of the Diabetes Specific Quality of Life scale, thus supporting the DCP’s criterion validity. The DCP is an acceptable measure of the psychosocial factors related to diabetes and its treatment in a Chinese population with type 2 diabetes. [ABSTRACT FROM PUBLISHER]

Background: As the first gene therapy for spinal muscular atrophy (SMA), nusinersen is supposed to be administrated via intrathecal injection regularly for a lifetime. However, for SMA patients with severe spinal deformities, bony fusion following posterior spinal instrumentation sets great obstacles for the application of nusinersen. Therefore, efforts have been devoted to the exploration of appropriate approach for nusinersen administration. This study aims to evaluate the safety and reliability of unilateral interlaminar fenestration on the convex side during spinal fusion surgery for intrathecal nusinersen injection in SMA. Results: SMA patients receiving posterior spinal fusion and interlaminar fenestration in Peking Union Medical College Hospital from January 2020 to October 2021 were retrospectively analyzed. 13 patients were included. Of the 13 patients, 10 were classified into SMA type II and 3 into SMA type III. Distal fusion to pelvis was undertaken in 11 patients; while L5 was selected as the lowest instrumented vertebra in the other 2 patients. All patients received interlaminar fenestration on the convex side only with an area of about 15 mm × 20 mm. Fenestration at L2–L3 level was performed in 6 patients; while L3–L4 level was selected for windowing in the remaining 7 patients. 9 of the 13 patients received lumbar puncture and intrathecal nusinersen administration during the 1-year follow-up, with an accumulative total of 50 times. All injections were performed successfully under ultrasound guidance, with no one transferred to radiographic assistance. No severe complications occurred after injection. Conclusions: In SMA with severe scoliosis planning to receive posterior spinal fusion, unilateral lumbar interlaminar fenestration on the convex side provides a feasible and reliable access for intrathecal nusinersen administration after surgery. [ABSTRACT FROM AUTHOR]

Areas containing industrial facilities belonging to three different typical industries that may cause pollution by polybrominated diphenyl ethers (PBDEs) in Beijing, China were investigated. Specifically, the areas contained a solid waste incineration plant, a chemical factory, and a heat and power plant. Investigation of the pollution status of PBDEs in the surface soil from areas around these industries revealed the highest concentration of 42 PBDE congeners (118 ng/g, dry mass) at the solid waste incineration plant. In the other two plants, the highest concentrations were both 26 ng/g (dry mass). Among the PBDE homologues, the PBDE contamination at all sites showed similar congener compositions, with BDE 209 being the dominant congener. Our findings established the first contamination status of three typical industrial areas in Beijing. Furthermore, the total concentrations of 42 PBDE congeners tended to decrease as the distance from the investigated plants increased. Overall, these plants were identified as potential pollution sources of PBDEs in Beijing. Moreover, Pearson correlation analysis revealed that the major PBDE source in Beijing may be associated with the technical deca-BDE and penta-BDE mixture. Based on the data obtained in this preliminary investigation, further study of the potential of these sources to emit PBDEs in Beijing is warranted. [ABSTRACT FROM AUTHOR]

In order to study the decay rate of the rail in some section of Beijing metro using the egg fastening system, a cellular rail model based on the spectral element method is established. In combination with Bloch theorem, the decay rate of the rail with the egg fastening system is hereby studied. On this basis, the influence of tuned rail damper (TRD) on the decay rate of the rail is analyzed. At present, the decay rate of the rail with the egg fastening system is relatively low, in the frequency range from 200 Hz to 400 Hz. The influence of the egg fastening system on the decay rate of the rail is mainly reflected in the frequency range below 450 Hz. TRD can greatly increase the decay rate of the rail in the vicinity of its operating frequency. Moreover, TRD damping can increase the decay rate of the rail, which is beneficial in controlling rail vibration. Rail vibration can be better controlled by increasing the weight of TRD when the operating frequency is constant. The installation position of TRD also affects the decay rate of the rail. Appropriate adjustment of this position can more effectively suppress rail vibrations over a wider frequency range. [ABSTRACT FROM AUTHOR]