1. Probable long‐term prevalence for a predominant Mycobacterium tuberculosis clone of a Beijing genotype in Colon, Panama.
- Author
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Acosta, Fermin, Norman, Anders, Sambrano, Dilcia, Batista, Victoria, Mokrousov, Igor, Shitikov, Egor, Jurado, Julio, Mayrena, Maritza, Luque, Odemaris, Garay, Maybis, Solís, Laura, Muñoz, Patricia, Folkvardsen, Dorte B., Lillebaek, Troels, Pérez‐Lago, Laura, Goodridge, Amador, and García de Viedma, Darío
- Subjects
MYCOBACTERIUM tuberculosis ,TANDEM repeats ,COLON (Anatomy) ,GENOTYPES ,NUCLEOTIDE sequencing ,TUBERCULOSIS - Abstract
Beijing genotype Mycobacterium tuberculosis strains associate with increased virulence, resistance and/or higher transmission rates. This study describes a specific Beijing strain predominantly identified in the Panamanian province of Colon with one of the highest incidences of tuberculosis in the country. Retrospective mycobacterial interspersed repetitive unit/variable number of tandem repeats analysis of 42 isolates collected between January and August 2018 allowed to identify a cluster (Beijing A) with 17 (40.5%) Beijing isolates. Subsequent prospective strain‐specific PCR‐based surveillance from September 2019 to March 2020 confirmed the predominance of the Beijing A strain (44.1%) in this province. Whole‐genome sequencing revealed higher‐than‐expected diversity within the cluster, suggesting long‐term prevalence of this strain and low number of cases caused by recent transmission. The Beijing A strain belongs to the Asian African 3 (Bmyc13, L2.2.5) branch of the modern Beijing sublineage, with their closest isolates corresponding to cases from Vietnam, probably introduced in Panama between 2000 and 2012. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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