1. Ambient particulate air pollution and circulating antioxidant enzymes: A repeated-measure study in healthy adults in Beijing, China.
- Author
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Wu, Shaowei, Wang, Bin, Yang, Di, Wei, Hongying, Li, Hongyu, Pan, Lu, Huang, Jing, Wang, Xin, Qin, Yu, Zheng, Chanjuan, Shima, Masayuki, Deng, Furong, and Guo, Xinbiao
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PHYSIOLOGICAL effects of air pollution ,ANTIOXIDANTS ,PARTICULATE matter ,SUPEROXIDE dismutase ,GLUTATHIONE peroxidase - Abstract
The association of systemic antioxidant activity with ambient air pollution has been unclear. A panel of 40 healthy college students underwent repeated blood collection for 12 occasions under three exposure scenarios before and after relocating from a suburban area to an urban area in Beijing, China in 2010–2011. We measured various air pollutants including fine particles (PM 2.5 ) and determined circulating levels of antioxidant enzymes extracellular superoxide dismutase (EC-SOD) and glutathione peroxidase 1 (GPX1) in the laboratory. An interquartile range increase of 63.4 μg/m 3 at 3-d PM 2.5 moving average was associated with a 6.3% (95% CI: 0.6, 12.4) increase in EC-SOD and a 5.5% (95% CI: 1.3, 9.8) increase in GPX1. Several PM 2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Our results support activation of circulating antioxidant enzymes following exposure to particulate air pollution. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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