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1. The impact of some parameters on linkage analysis of Alzheimer's disease.

Author

Xu JF, Taylor EW, Lung FW, Chung AS, Chase GA, Maestri NE, and Meyers DA

Subjects
Adult, Aged, Aged, 80 and over, Alleles, Alzheimer Disease epidemiology, Boston epidemiology, Gene Frequency, Genetic Markers, Humans, Lod Score, Middle Aged, Alzheimer Disease genetics, Genetic Linkage
Abstract

The two-point lod score linkage analysis of familial Alzheimer's disease is sensitive to the parameters of age-dependent penetrance rate, phenocopy rate, heterogeneity, and marker gene frequency. If unsuitable parameters are used, it may lead to false negative evidence against linkage. However, it is clear that, in some cases, it may lead to false positive evidence of linkage.

Published
1993
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