1. Fasting insulin resistance affects the prevalence of metabolically healthy obesity in Brazilian adolescents.
- Author
-
Marra NF, Bechere Fernandes MT, de Melo ME, da Cruz RM, and Tess BH
- Subjects
- Adolescent, Age Factors, Brazil epidemiology, Child, Cross-Sectional Studies, Female, Humans, Male, Prevalence, Puberty, Retrospective Studies, Sex Factors, Insulin Resistance, Obesity, Metabolically Benign epidemiology, Pediatric Obesity epidemiology
- Abstract
Aim: We aimed to assess the influence of fasting insulin resistance on metabolically healthy obesity (MHO) prevalence in adolescents and to identify associated factors., Methods: This retrospective, registry-based, cross-sectional study included 418 (51.9% girls) 10- to 18-year-old adolescents with obesity from a tertiary outpatient clinic in Sao Paulo, Brazil, between 2009 and 2013. The prevalence of MHO was estimated according to two definitions: (i) no cardiometabolic risk factors (CMRF) by the International Diabetes Federation parameters and (ii) no CMRF and homeostatic model assessment for insulin resistance <3.16. Adjusted prevalence ratios and 95% confidence intervals (CI) evaluated the association of gender, age, pubertal stages, skin colour and degree of obesity with MHO., Results: Metabolically healthy obesity prevalence was lower in definition II than definition I (12.7%; 95% CI 9.1-16.3% versus 43.1%; 95% CI 38.0-48.2%, respectively). Adjusted results showed negative association between severe obesity and MHO by both definitions (p ≤ 0.01). Male and later pubertal stages were also less likely to have MHO, but neither remained significant in definition II., Conclusion: Metabolically healthy obesity prevalence decreased when insulin resistance was part of the definition. Detecting pre-clinical insulin resistance may improve the management of treatment-seeking adolescents, especially when they present no CMRF., (©2018 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
- Published
- 2019
- Full Text
- View/download PDF