1. Incidence of Cytomegalovirus Antigenemia in patients with autoimmune rheumatic diseases: a 3-year retrospective study.
- Author
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Santos RP, Dos Reis-Neto ET, and Pinheiro MM
- Subjects
- Adolescent, Adrenal Cortex Hormones therapeutic use, Adult, Aged, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis drug therapy, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis mortality, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis virology, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid mortality, Arthritis, Rheumatoid virology, Bone Marrow immunology, Bone Marrow virology, Brazil epidemiology, Female, Granulomatosis with Polyangiitis immunology, Granulomatosis with Polyangiitis virology, Humans, Immunosuppressive Agents therapeutic use, Intestines immunology, Intestines virology, Lung immunology, Lung virology, Lupus Erythematosus, Systemic drug therapy, Lupus Erythematosus, Systemic mortality, Lupus Erythematosus, Systemic virology, Male, Middle Aged, Retrospective Studies, Rheumatic Fever immunology, Rheumatic Fever virology, Time Factors, Young Adult, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis immunology, Antigens, Viral blood, Arthritis, Rheumatoid immunology, Cytomegalovirus immunology, Cytomegalovirus Infections immunology, Lupus Erythematosus, Systemic immunology
- Abstract
Objective: To determine the incidence of positive CMV antigenemia (CMV-Ag) in patients with autoimmune rheumatic diseases (AIRD) and to describe the outcomes of these patients., Methods: From January 2011 to December 2014, a total of 443 patients with AIRD were enrolled in this retrospective analysis. Demographic, clinical and laboratory data, current clinical manifestations, organs affected by CMV infection, therapeutic management and outcomes were evaluated. The CMV-Ag was considered positive when one cell was detected at least., Results: CMV-Ag was requested in 70 (15.8%) patients with suspicious CMV infection and was positive in 24 (34.3%). The incidence rate of positive CMV-Ag was 4.97% (95% CI 3.1-7.4%). Systemic lupus erythematosus (SLE) (59%), followed by ANCA-related vasculitis (18.2%) and rheumatoid arthritis (9%) were the diseases more associated with positive CMV-Ag. At the time of CMV infection, SLE patients had moderate to severe disease activity, with high frequency of positive anti-dsDNA antibody (69.2%) and complement consumption (61.5%), as well as high doses of corticosteroids and use of immunosuppressants. The main CMV sites involved were lung (45.5%), bone marrow (40.9%) and gut (27.3%). Mortality rate was 45.5%, especially in those with higher doses of daily oral corticosteroids (107 ± 55.4 mg vs. 71.7 ± 46.3 mg; p = 0.07) and lower number of lymphocytes (309 ± 368.2/mm
3 vs. 821 ± 692.9/mm3 ; p = 0.06)., Conclusions: Our data showed high incidence of CMV-Ag in AIRD patients, particularly those with SLE and greater disease severity. In addition, it was observed high mortality in these patients, highlighting the CMV infection should be included in differential diagnosis.- Published
- 2019
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