1. Maternal ophthalmic artery Doppler ultrasonography in preeclampsia and pregnancy outcomes.
- Author
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Chaves, Maria Teresa Pedrazzi, Martins-Costa, Sérgio, Oppermann, Maria Lúcia da Rocha, Dias, Ricardo Palma, Magno, Valentino, Peña, Julio Alejandro, Ramos, José Geraldo Lopes, and Palma Dias, Ricardo
- Subjects
OPHTHALMIC artery ,APGAR score ,BLOOD flow measurement ,EYE ,FETAL ultrasonic imaging ,HEMODYNAMICS ,LONGITUDINAL method ,EVALUATION of medical care ,PREECLAMPSIA ,PREGNANCY ,PHYSIOLOGY - Abstract
Objective: To examine the association of ophthalmic artery (OA) Doppler measure - the ratio of velocity peaks (PR) - to adverse pregnancy outcomes in preeclampsia.Study Design and Main Outcomes: Prospective cohort study of 56 women with preeclampsia that underwent Doppler measurements of OA flow, medial to optic nerve. PR results were classified as normal (PR < 0.78), abnormal (PR 0.78-0.98), or highly abnormal (PR ≥ 0.99). Attending clinicians were blinded to OA Doppler results. The primary endpoints were (1) a composite of adverse maternal outcomes-central nervous system injury (eclampsia or posterior reversible encephalopathy syndrome), HELLP syndrome, hypertensive crisis, maternal admission to the intensive care unit, and maternal death-and (2) a composite of adverse perinatal outcomes-birth weight <10th percentile for gestational age, neonatal acidemia, 5-min Apgar score <7, admission of infants weighing >2500 g to the neonatal intensive care, preterm birth <32 weeks, fetal or neonatal death.Results: Adverse maternal outcomes became more frequent as the PR values increased (p=.005). The occurrence of hypertensive crisis after hospital admission (secondary endpoint) was also positively associated with PR values (p=.001). Adverse perinatal outcomes were not associated with PR values (p=.551), but women in the highly abnormal PR group (PR ≥ 0.99) had the earliest deliveries (p=.001) and the smallest newborns (p=.004). All women in the highly abnormal PR group (n=16) had an adverse outcome.Conclusions: Maternal OA Doppler PR ≥ 0.99 in preeclampsia may identify women at increased risk of adverse maternal outcomes and pregnancies at the greatest risk of preterm birth. [ABSTRACT FROM AUTHOR]- Published
- 2017
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