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• Classical forensic compound analysis can lead to erroneous conclusions. • Compositional approaches yield unbiased and better interpretable results. • Compositional methods boost performance, reducing misclassification rates. • For the analysis of petrol compounds, the log-ratio approach should be used. In recent years, numerous studies have examined the chemical compounds of petrol and petrol data for forensic research. Standard quantitative methods often assume that the variables or compounds do not have compositional constraints or are not part of a constrained whole, operating within an Euclidean vector space. However, chemical compounds are typically part of a whole, and the appropriate vector space for their analysis is the simplex. Biased and arbitrary results result when statistical analysis are applied on such data without proper pre-processing of such data. Compositional analysis of data has not yet been considered in forensic science. Therefore, we compare classical statistical analysis as applied in forensic research and the new proposed paradigm of compositional data analysis (CoDa). It is demonstrated how such analysis improves the analysis in petrol and forensic science. Our study shows how principal component analysis (PCA) and classification results are affected by the preprocessing steps performed on the raw data. Our results indicate that results from a log ratio analysis provides a better separation between subgroups of the data and leads to an easier interpretation of the results. In addition, with a compositional analysis a higher classification accuracy is obtained. Even a non-linear classification method - in our case a random forest - was shown to perform poorly when applied without using compositional methods. Moreover, normalization of samples due to laboratory/unit-of-measurement effects is no longer necessary, since the composition of an observation is in compositional thinking equivalent to a multiple of it, because the used (log) ratios on raw and log ratio transformed data are equal. Petrol data from different petrol stations in Brazil are used for the demonstration. This data is highly susceptible to counterfeit petrol. Forensic analysis of its chemical elements requires non-biased statistical analysis designed for compositional data to detect fraud. Based on these results, we recommend the use of compositional data methods for gasoline and petrol chemical element analysis and gasoline product characterization, authentication and fraud detection in forensic sciences. [ABSTRACT FROM AUTHOR]

Latin American foreign-policy elites defend the principle of non-intervention to shield their countries' autonomy. By 2005, however, most Latin American foreign policy elites accepted the easing of limits on the use of force in international law. They supported the Responsibility to Protect (R2P), which regulates the use of force to protect populations from mass atrocities. The paper presents a comparison of the Brazilian, Chilean, and Mexican positions in the R2P debates to understand why they supported this norm. During the debates leading to the emergence of R2P, these elites questioned a central premise of liberal internationalism: the idea that great powers would restrain their use of military force as part of their commitment to a liberal international order (LIO). Using Republican international political theory, I argue that these Latin American foreign-policy elites viewed a restricted humanitarian-intervention norm as a new defence against great powers interfering in developing countries. Instead of trusting that great powers would restrain their actions, these elites advocated for a humanitarian-intervention norm that would prevent uncontrolled humanitarian interventions. [ABSTRACT FROM AUTHOR]

This article explores why, by 2005, most Latin American countries supported the Responsibility to Protect (R2P), a doctrine modifying limits on the use of force to address atrocity crimes. I group existing explanations of why Latin American countries apparently changed their long-standing defence of non-intervention following the main explanatory factor they focus on: power asymmetries, government preferences or coalition politics. I find that these accounts downplay a fundamental dimension informing the approaches of Latin American supporters: how to limit interveners. Drawing on Republican security theory (RST), I argue that Latin American supporters faced a dilemma in the R2P debates, especially after the intervention in Iraq in 2003. Latin American supporters favoured crafting solutions to humanitarian problems that simultaneously addressed crises and prevented arbitrary uses of force. I use the Brazilian and Chilean case studies to explore this argument. Brazilian and Chilean governments concluded that their conventional interpretations of limits on the use of force did not offer answers for both humanitarian emergencies and arbitrary uses of force. As a solution, they modified but did not abandon their diplomatic traditions. These governments calculated that humanitarian-intervention norms could be constraints, even if imperfect, on interveners arbitrarily using military force. [ABSTRACT FROM AUTHOR]

Background and Purpose: The diagnostic criteria for myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) were published in 2023. We aimed to determine the performance of the new criteria in Latin American (LATAM) patients compared with the 2018 criteria and explore the significance of MOG-IgG titers in diagnosis., Methods: We retrospectively reviewed the medical records of LATAM (Argentina, Chile, Brazil, Peru, Ecuador, and Colombia) adult patients with one clinical MOGAD event and MOG-IgG positivity confirmed by cell-based assay. Both 2018 and 2023 MOGAD criteria were applied, calculating diagnostic performance indicators., Results: Among 171 patients (predominantly females, mean age at first attack = 34.1 years, mean disease duration = 4.5 years), 98.2% patients met the 2018 criteria, and of those who did not fulfill diagnostic criteria (n = 3), all tested positive for MOG-IgG (one low-positive and two without reported titer). Additionally, 144 (84.2%) patients met the 2023 criteria, of whom 57 (39.5%) had MOG-IgG+ titer information (19 clearly positive and 38 low-positive), whereas 87 (60.5%) patients had no MOG-IgG titer. All 144 patients met diagnostic supporting criteria. The remaining 27 patients did not meet the 2023 MOGAD criteria due to low MOG-IgG (n = 12) or lack of titer antibody access (n = 15), associated with the absence of supporting criteria. The 2023 MOGAD criteria showed a sensitivity of 86% (95% confidence interval = 0.80-0.91) and specificity of 100% compared to the 2018 criteria., Conclusions: These findings support the diagnostic utility of the 2023 MOGAD criteria in an LATAM cohort in real-world practice, despite limited access to MOG-IgG titration., (© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)

Background: Neuromuscular impairment makes individuals with cerebral palsy (CP) more prone to drooling. Among the treatment options, there are procedures that interfere with saliva production. It is imperative to evaluate the effect of the different modalities since the reduction in salivary flow rate/production may exacerbate the risk of dental caries., Material and Methods: The aim of this study was to compare the effects of different treatments for drooling on caries risk and salivary parameters in children and adolescents with CP., Study Design: A total of 142 children and adolescents with CP, aged 6 to 18 years, were assigned to groups based on the different treatments they had received for drooling: G1-anticholinergic drugs (n = 18), G2-botulinum toxin injection (n = 16), G3-salivary glands surgery (n = 16), G4-no treatment (n = 42), and G5-non-drooling subjects (n = 50). All participants were evaluated on the Simplified Oral Hygiene Index, and for the prevalence of dental caries (decayed, missing, and filled teeth index and white spot lesions). Unstimulated whole saliva was collected, and salivary flow rate and osmolality were measured. Chi-square, ANOVA and Poisson regression were calculated. Prevalence ratios and their respective 95 % confidence intervals were obtained. The significance level was fixed at 5%., Results: No differences were found in the decayed, missing, and filled teeth index (p = 0.128) and Simplified Oral Hygiene Index (p = 0.674) among the different groups. G3 presented significantly higher percentages of WSL (p < 0.001), lower values of salivary flow rate (p < 0.001), and higher values of osmolality (p < 0.001). The white spot lesion prevalence ratio was higher only for G3 (Prevalence ratio = 14.36; IC 95% = 4.64-44.40; p < 0.001)., Conclusions: Children and adolescents with CP who had received surgical treatment for drooling exhibited higher number of white spot lesions because of the reduced salivary flow rate and higher salivary osmolality.