1. No Association of Polymorphisms in Nav1.7 or Nerve Growth Factor Receptor Genes with Trigeminal Neuralgia.
- Author
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Costa, Grazielle Mara Ferreira, Rocha, Luiz Paulo C, Siqueira, Silvia Regina Dowgan Tesseroli de, Moreira, Paula Rocha, and Almeida-Leite, Camila Megale
- Subjects
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ALLELES , *CELL receptors , *GENE expression , *GENETIC polymorphisms , *MEMBRANE proteins , *ORAL disease diagnosis , *NERVE growth factor , *POLYMERASE chain reaction , *QUESTIONNAIRES , *PAIN measurement , *TRIGEMINAL neuralgia , *VISUAL analog scale , *SEVERITY of illness index , *GENOTYPES , *DISEASE risk factors - Abstract
Objective Trigeminal neuralgia is defined as a sudden severe shock-like pain within the distribution of the trigeminal nerve. Pain is a subjective experience that is influenced by gender, culture, environment, psychological traits, and genes. Sodium channels and nerve growth factor play important roles in the transmission of nociceptive signals and pain. The aim of this study was to investigate the occurrence of Nav1.7 sodium channel and nerve growth factor receptor TrkA gene polymorphisms (SCN9A/rs6746030 and NTRK1/rs633, respectively) in trigeminal neuralgia patients. Methods Ninety-six subjects from pain specialty centers in the southeastern region of Brazil were divided into 2 groups: 48 with classical trigeminal neuralgia diagnosis and 48 controls. Pain was evaluated using the visual analog scale and multidimensional McGill Pain Questionnaire. Genomic DNA was obtained from oral swabs in all individuals and was analyzed by real-time polymerase chain reaction. Results No association was observed between evaluated polymorphisms and trigeminal neuralgia. For allele analyses, patients and controls had similar frequencies for both genes. Genotype distribution or allele frequencies of polymorphisms analyzed here did not correlate to pain scores. Conclusions Although no association of evaluated polymorphisms and trigeminal neuralgia diagnosis or pain severity was observed, our data do not exclude the possibility that other genotypes affecting the expression of Nav1.7 or TrkA are associated with the disease. Further studies should investigate distinct genetic polymorphisms and epigenetic factors that may be important in expression of these molecules. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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