1. The role of porphyrin chemistry in tumor imaging and photodynamic therapy.
- Author
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Manivannan Ethirajan, Yihui Chen, Penny Joshi, and Ravindra K. Pandey
- Subjects
PORPHYRINS ,IMAGING of cancer ,PHOTOCHEMOTHERAPY ,WAVELENGTHS ,PHOTOSENSITIZERS - Abstract
In recent years several review articles and books have been published on the use of porphyrin-based compounds in photodynamic therapy (PDT). This critical reviewis focused on (i) the basic concept of PDT, (ii) advantages of long-wavelength absorbing photosensitizers (PS), (iii) a brief discussion on recent advances in developing PDT agents, and (iv) the various synthetic strategies designed at the Roswell Park Cancer Institute, Buffalo, for developing highly effective long-wavelength PDT agents and their utility in constructing the conjugates with tumor-imaging and therapeutic potential (Theranostics). The clinical status of certain selected PDT agents is also summarized (205 references). [ABSTRACT FROM AUTHOR]
- Published
- 2010