1. Field studies of drug-resistant cattle trypanosomes in Ke´ne´dougou Province, Burkina Faso
- Author
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McDermott, John, Woitag, Tanja, Sidibé, Issa, Bauer, Burkhard, Diarra, Boucader, Ouédraogo, Denis, Kamuanga, Mulumba, Peregrine, Andrew, Eisler, Mark, Zessin, Karl-Heinz, Mehlitz, Dieter, and Clausen, Peter-Henning
- Subjects
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TRYPANOSOMA - Abstract
Field studies were conducted to assess the occurrence of resistance to isometamidium chloride and diminazene aceturate in trypanosomes infecting cattle in Ke´ne´dougou Province of Burkina Faso. Forty-five of the 166 villages in Ke´ne´dougou were randomly sampled and visited to assess livestock numbers, trypanosomosis risk, and tsetse challenge. The proportion of cattle infections associated with drug-resistant trypanosomes was assessed in the nine villages with the highest trypanosome infection prevalence and one village with a confirmed history of drug-resistant infections. These studies showed that resistance to both isometamidium and diminazene was widespread. However, there was considerable variation between villages in drug-resistance parameters, with the proportion of treated cattle with trypanosome infections 3 months after isometamidium prophylaxis varying from 6.9 to 63.8% and the proportion of cattle having infections 2 weeks after treatment with diminazene varying from 0 to 36.8%. The demonstration of widespread resistance to both isometamidium and diminazene has important implications, as administration of trypanocides is the most commonly employed method to control trypanosomosis in this area. [Copyright &y& Elsevier]
- Published
- 2003
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