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Introduction: The transition age is the period between childhood to adulthoo d; it refers to a broad set of physical, cognitive and sociocultural modifications, arbitrarily defined as starting in late puberty and ending with full adult maturation. Pituitary disorders in adolescence represent a chal lenge that requires careful management during the transition to adult care. Methods: Given the complexity of care of pituitary disorders in the tra nsition age, we have reviewed the relevant medical literature focusing on aetiology, clinical manifestations, treatment strategies of GH deficiency (GHD), hypogonadotrophic hypogonadism (HH) in male and female adolesce nts, central hypothyroidism (CH), central adrenal insufficiency (CAI) and cranial diabetes insipidus (CDI) at this time. The objective of the present review is to provide an up-to-date evaluation of the transition period to evaluate the specific needs of adolescents with chronic pituitary disease in order to optimise their management. Results: We provide an overview of current clinical management of GHD, HH, CH, CAI and CDI in the transition age. Conclusions: Specific changes occur in pituitary function during the transit ion period. A holistic approach including discussion of patients' concerns and emotional support should c onstitute a key component of managing pituitary disorders in adolescence. Special transition clinics where paed iatric and adult endocrinologists work together, should be increasingly created and strengthened to bridge care, to pro mote continuity and adherence to treatment and to limit potential negative development, metabolic, skeletal and c ardiovascular sequelae of discontinuity of care among adolescents with pituitary disorders. [ABSTRACT FROM AUTHOR]