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Superficial sediments were taken at the port of Cagliari (Sardinia, Italy), which includes the oil terminal of one of the largest oil refineries in the Mediterranean. Significant trace metal concentrations were found in the whole port area. Sequential extraction of metals from the different sediment fractions (BCR method) showed a higher risk of remobilisation for Cd, which is mostly bound to the exchangeable fraction. Foraminiferal density and richness of species were variable across the study area. The living assemblages were characterized by low diversity in samples collected close to the port areas. Ammonia tepida and bolivinids, which were positively correlated with concentrations of heavy metals and organic matter content, appeared to show tolerance to the environmental disturbance. The sampling sites characterized by the highest values of biotic indices were located far from the port areas and present an epiphytic and epifaunal biocoenosis. [ABSTRACT FROM AUTHOR]

In order to analyse the impact of a new train service in Cagliari (Italy) a databank including information from a revealed preference (RP) and a stated preference (SP) survey was set up. The RP data concern choice between car, bus and train; the SP data consider the binary choice between a new train service (quicker, more frequent, with a lower fare and more stations than the current one) and the alternative currently chosen by car and bus users. Logit models allowing for correlation among RP alternatives were estimated for this mixed RP/SP data set using the artificial tree structure method. The analysis included level-of-service variables measured with an unusually high level of precision, latent or second order variables (such as comfort), inertia and interaction variables. Different specifications of the utility function were tested, including the expenditure rate model, and the effects of these specifications on modelling results are highlighted. Our results show that for a population mainly composed of fixed income workers, the expenditure rate model is superior to the traditional wage rate model, yielding lower and more significant subjective values of time. Moreover, we found that the non-linear specifications appear to be more suitable as not only better model results were obtained, but also the real distribution of the error terms was revealed (i.e. highlighting correlation among public transport options). [ABSTRACT FROM AUTHOR]

Since chronic inflammation is associated with ovarian cancer growth and progression, some clinical studies have assessed the association between the pre-treatment neutrophil-to-lymphocyte ratio (NLR) and the prognosis of ovarian cancer. The purpose of this study was to assess the dynamic behavior of the NLR during the course of neoadjuvant chemotherapy (NACT) in patients with high grade serous (HGS) advanced epithelial ovarian cancer and assess its correlation with clinical response, progression free survival (PFS) and changes in other inflammatory indexes. We performed a prospective observational study on 161 patients who underwent NACT at the Department of Gynecologic Oncology, ARNAS G. Brotzu, Cagliari, between 2009 and 2019. NLR was evaluated before starting and after three cycles of NACT. Based on response after three cycles of NACT, patients were divided into two groups: responsive and non-responsive. The primary endpoint was to assess the predictive role of NLR by comparing the responsive and non-responsive patients at baseline and after three cycles of NACT. Secondary endpoints were (a) to correlate NLR with other inflammation markers (CRP, fibrinogen, ferritin, IL-6), albumin, and modified Glasgow Prognostic Score (mGPS) with NLR at baseline and after NACT; (b) to assess the association between NLR and PFS. We found that the NLR value at baseline was not associated with response to NACT, while a decrease in NLR after three cycles was correlated with a better response to NACT. Also, values of CRP, IL-6, ferritin, and mGPS after three cycles of NACT (but not at baseline) were significantly associated with clinical response. Moreover, we found that patients with a low NLR value after 3 cycles of NACT, but not at baseline, had a significantly higher PFS than patients with high NLR after 3 cycles of NACT. In conclusion, NLR change during treatment could serve as a predictive marker of response to NACT in patients with HGS advanced ovarian cancer. This allows for the early identification of non-responsive patients who will need treatment remodeling. [ABSTRACT FROM AUTHOR]