1. Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women.
- Author
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Greenblatt RM, Jacobson LP, Levine AM, Melnick S, Anastos K, Cohen M, DeHovitz J, Young MA, Burns D, Miotti P, and Koelle DM
- Subjects
- Adult, California epidemiology, Cocaine, Cohort Studies, Crack Cocaine, Cross-Sectional Studies, District of Columbia epidemiology, Female, HIV Seronegativity, Heroin, Herpesviridae Infections epidemiology, Humans, New York epidemiology, Prevalence, Risk Factors, Sarcoma, Kaposi epidemiology, Seroepidemiologic Studies, Sex Factors, Substance Abuse, Intravenous, Syphilis complications, Antibodies, Viral blood, HIV Infections complications, HIV Seropositivity complications, Herpesviridae Infections complications, Herpesvirus 8, Human immunology, Sarcoma, Kaposi complications
- Abstract
Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P<.001), past syphilis (29% vs. 20%; P<.001), an injection drug-using male sex partner (61% vs. 53%; P=.014), black race (P=.010), and enrollment site (P=.015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.
- Published
- 2001
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