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This paper addresses a few issues that are fundamental for the understanding of vegetation–topography relations: scale dependency, seasonal variability, and importance of observing individual properties. Particularly, it uses two statistical tools – Pearson''s r and Moran''s I – to define relationships of several topographic attributes with the Normalized Difference Vegetation Index (NDVI), the Normalized Difference Infrared Index (NDII), and their seasonal changes (from May to July and then September) in the Mediterranean-type landscape of the Santa Monica Mountains, California. The analyses are conducted at both the original data resolution and 20 aggregated resolutions, covering a total range of 30 m to 1500 m, so that topography–vegetation relationships can be compared at different scales. Large sample sizes have supported the significance of the following main findings for this landscape. First, elevation, slope, and southness are the most relevant primary topographic attributes among the tested attributes and their importance changes across seasons. Second, NDVI, NDII, and their seasonal variations have notably different relationships (including no relationship) with topography. Third, the observed topography–vegetation correlations (r) tend to change – typically increase – with the coarsening of spatial scale. Lastly, the spatial autocorrelation of vegetation variables and topographic attributes are often comparable, and the comparability is more apparent when topography–vegetation correlations are stronger. In all, the topography–NDVI/NDII relations defined in this paper may improve the understanding of the multi-scale and property-specific role that mountain topography plays in the formation and seasonal change of vegetation patterns. [Copyright &y& Elsevier]